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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 220-239-6 | CAS number: 2682-20-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.021 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: In accordance with the biocidal product regulation
- Overall assessment factor (AF):
- 16
- Dose descriptor:
- NOAEC
- Value:
- 0.34 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- MOA is irritation which is a threshold mediated effect
- AF for differences in duration of exposure:
- 2
- Justification:
- Additional duration factor applied as extrapolating from a subchronic study to chronic duration
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for other interspecies differences:
- 1
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for intraspecies differences:
- 3.2
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for the quality of the whole database:
- 1
- Justification:
- Well studied molecule with hazards well characterized
- AF for remaining uncertainties:
- 1
- Justification:
- No uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.043 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: In accordance with the biocidal product regulation
- Overall assessment factor (AF):
- 8
- Dose descriptor starting point:
- NOAEC
- Value:
- 0.34 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- MOA is irritation which is a threshold mediated effect
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for other interspecies differences:
- 1
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for intraspecies differences:
- 3.2
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for the quality of the whole database:
- 1
- Justification:
- Well studied molecule with hazards well characterized
- AF for remaining uncertainties:
- 1
- Justification:
- No uncertainties
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.021 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: Accordance with the BPR
- Overall assessment factor (AF):
- 16
- Dose descriptor:
- NOAEC
- Value:
- 0.34 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- MOA is local irritation which is concentration dependent and threshold mediated
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolating from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for other interspecies differences:
- 1
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for intraspecies differences:
- 3.2
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for the quality of the whole database:
- 1
- Justification:
- Hazards well characterised in well conducted studies
- AF for remaining uncertainties:
- 1
- Justification:
- No remiaing uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.043 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: MOA is direct reactivity and therefore metabolism not involved
- Overall assessment factor (AF):
- 8
- Dose descriptor starting point:
- NOAEC
- Value:
- 0.34 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Effects are concentration dependent, threshold mediated
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for other interspecies differences:
- 1
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for intraspecies differences:
- 3.2
- Justification:
- MOA is direct reactivity and therefore metabolism not involved
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.027 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: Accordance with conclusions of the review of the active substance under the BPR
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 10 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 5.3 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Corrected for oral absorption factor of 53%
- AF for dose response relationship:
- 1
- Justification:
- MOA is local irritation of the GI tract
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from subchronic to chronic duration
- AF for interspecies differences (allometric scaling):
- 10
- Justification:
- Standard
- AF for other interspecies differences:
- 1
- Justification:
- Standard
- AF for intraspecies differences:
- 10
- Justification:
- Standard
- AF for the quality of the whole database:
- 1
- Justification:
- MIT is well studied, hazards are well characterised
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.053 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: Accordance with conclusions of the review of the active substance under the BPR
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 10 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 5.3 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Corrected for oral absorption factor of 53%
- AF for dose response relationship:
- 1
- Justification:
- MOA is local irritation of the GI tract
- AF for interspecies differences (allometric scaling):
- 10
- Justification:
- Standard
- AF for other interspecies differences:
- 1
- Justification:
- Standard
- AF for intraspecies differences:
- 10
- Justification:
- Standard
- AF for the quality of the whole database:
- 1
- Justification:
- MIT is well studied, hazards are well characterised
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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