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EC number: 203-517-1 | CAS number: 107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.10.2017 to 26.10.2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- BioChem agrar, Labor für biologische und chemische Analytik GmbH, Kupferstr. 6, 04827 Machem OT Gerichshain (Germany)
Test material
- Reference substance name:
- 3,7-dimethyloctane-1,7-diol
- EC Number:
- 203-517-1
- EC Name:
- 3,7-dimethyloctane-1,7-diol
- Cas Number:
- 107-74-4
- Molecular formula:
- C10H22O2
- IUPAC Name:
- 3,7-dimethyloctane-1,7-diol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Miltitz Aromatics GmbH (Bitterfeld-Wolfen, Germany), Batch No.: BM 7/17, Lot No.: 239/17
- Expiration date of the lot/batch: 14.06.2019
- Purity test date: 14.06.2017
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: hydroxycitronellol was stored in the original container, at room temperature (at BioChem agrar GmbH: at ca. 20°C, dark and dry)
- Stability under test conditions: yes
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no
- Final dilution of a dissolved solid, stock liquid or gel: Due the water solubility of the test item ca. 30 g/L at 25°C), a stock solution was prepared. The desired test concentration of ca. 100 mg/L was achieved by dilution.
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test item hydroxycitronellol is soluble in water (ca. 30 g/L at 25°C). A stock solution was prepared by weighing of 53 mg test item into a graduated flask and filling up to 500 mL using test medium. The test solutions were prepared directly in the test vessels.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea (Daphnia magna Straus)
- Source: Origin of the test organism: RWTH Aachen University, Institute for Environmental Research (Biology V), Worringerweg 1, 52074 Aachen Germany); origin of the animals used in the test: test animals held and bred in the test facility under standardised laboratory conditions, test animals derived from a healthy stock, not first brood progeny
- Age of parental stock (mean and range, SD): not reported
- Feeding during test: no
ACCLIMATION: not necessary
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 232 mg/L CaCO3 (test medium)
- Test temperature:
- 19.7-20.5°C in all test vessels during the test
- pH:
- 7.76-7.87 in all test vessels during the test
- Dissolved oxygen:
- 8.67-8.79 mg/L in all test vessels during the test
- Conductivity:
- 1.3 µS/cm (test medium)
- Nominal and measured concentrations:
- 100 mg/L nominal
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass/25 mL/-/10 mL
- Aeration: no
- Type of flow-through (e.g. peristaltic or proportional diluter): study conducted under static conditions
- Renewal rate of test solution (frequency/flow rate): not applicable (study conducted under static conditions)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4 (+3 additional vessels: 1 for measuring of water parameters, 1 for analysis, 1 retain specimen)
- No. of vessels per control (replicates):4 (+3 additional vessels: 1 for measuring of water parameters, 1 for analysis, 1 retain specimen)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
- Alkalinity: 0.8 mmol/L
- Ca/Mg ratio: 4:1
- Conductivity: 1.3 µS/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light/8 h dark
- Light intensity: ca. 20 µE/m² x s
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mobility
VEHICLE CONTROL PERFORMED: no (no veheicle used)
RANGE-FINDING STUDY: performance not reported - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- In the most recent study, the 24 h EC50 was determined to be 1.34 mg/L potassium dichromate. Thus, the reference item EC50 was within the expected range of toxicity (1.0-2.0 mg/L).
- Reported statistics and error estimates:
- Due to the test results, nstatistical calculations were performed.o
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In an acute toxicity test, the 48 h NOEC, LOEC, and EC50 values based on a nominal test concentration were determined to be >=100, >100, and >100 mg/L hydroxycitronellol, respectively.
- Executive summary:
The acute toxicity of hydroxycitronellol to Daphnia magna was investigated in a study conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test; 2004). In this limit test, 20 daphnids were exposed to a nominal concentration of 100 mg/L under static conditions for 48 h. Immobility and abnormal behaviour/symptoms of the test animals were recorded. The 48 h NOEC, LOEC, and EC50 values based on a nominal test concentration were determined to be >=100, >100, and >100 mg/L, respectively.
The study is well documented and can be classified as reliable without restrictions satisfying the guideline requirements for an acute toxicity study with invertebrates.
Results Synopsis
Test organism/age: Daphnia magna (<24 h old)
Test Type: static
48 h NOEC: >=100 mg/L (nominal)48 h LOEC: >100 mg/L (nominal)
48 h EC50: >100 mg/L (nominal)
Endpoint(s) Effected: mobility, behaviour/symptoms
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