Registration Dossier
Registration Dossier
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EC number: 252-279-5 | CAS number: 34907-26-1
Endpoint summary
Administrative data
Description of key information
Read-across molecule 2,4-dinitrotoluene has a LD50 of 50 mg/kg (according to EU RAR in the cat based on increased levels of methhaemoglobin, cat is more sensitive species than rat (rat model likely o underpredict effect of methhaemoglobinemia LD50 of 400mg/kg in rat). Based on CLP (1272/2008) 2,4-dinitrotoluene would be classified as Category 3 for Oral Acute Toxicity.
The worst case acute oral toxicity value for the cat from 2,4-dinitrotoluene, LD50 of 50 mg/kg will be utilised to classify N,N,N-trimethyl-nitroanilinium chloride. Based on CLP (1272/2008) N,N,N-trimethyl-nitroanilinium chloride would be classified as Category 3 for Oral Acute Toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- Red across, study dates not available.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Read across to 2,3-dinitrotoluene - see attached document for details.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Read across to 2,4-dinitrotoluene EU RAR assessment
- GLP compliance:
- not specified
- Test type:
- other: Read across to 2,4-dinitrotoluene EU RAR assessment, enpoint only available
- Specific details on test material used for the study:
- Read across to 2,4-dinitrotoluene EU RAR assessment
- Species:
- cat
- Strain:
- not specified
- Remarks:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details
- Route of administration:
- other: Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details
- Vehicle:
- not specified
- Remarks:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details
- Mortality:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details available.
- Clinical signs:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details available.
- Body weight:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details available.
- Gross pathology:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details available.
- Other findings:
- Read across to 2,4-dinitrotoluene EU RAR assessment, only enpoint available, no study details available.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Read-across molecule 2,4-dinitrotoluene has a LD50 of 50 mg/kg (according to EU RAR in the cat based on increased levels of methhaemoglobin, cat is more sensitive species than rat (rat model likely o underpredict effect of methhaemoglobinemia LD50 of 400mg/kg in rat). Based on CLP (1272/2008) 2,4-dinitrotoluene would be classified as Category 3 for Oral Acute Toxicity.
The worst case acute oral toxicity value for the cat from 2,4-dinitrotoluene, LD50 of 50 mg/kg will be utilised to classify N,N,N-trimethyl-nitroanilinium chloride. Based on CLP (1272/2008) N,N,N-trimethyl-nitroanilinium chloride would be classified as Category 3 for Oral Acute Toxicity. - Executive summary:
Read-across molecule 2,4-dinitrotoluene has a LD50 of 50 mg/kg (according to EU RAR in the cat based on increased levels of methhaemoglobin, cat is more sensitive species than rat (rat model likely o underpredict effect of methhaemoglobinemia LD50 of 400mg/kg in rat). Based on CLP (1272/2008) 2,4-dinitrotoluene would be classified as Category 3 for Oral Acute Toxicity.
The worst case acute oral toxicity value for the cat from 2,4-dinitrotoluene, LD50 of 50 mg/kg will be utilised to classify N,N,N-trimethyl-nitroanilinium chloride. Based on CLP (1272/2008) N,N,N-trimethyl-nitroanilinium chloride would be classified as Category 3 for Oral Acute Toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 50 mg/kg bw
Additional information
Justification for classification or non-classification
There is sufficient evidence of short term oral toxicity from the available read-across molecules. The worst case was adopted (2,4-dinitrotoluene has a LD50 of 50 mg/kg in cats) to classify N,N,N-trimethyl-nitroanilinium chloride. Based on CLP (1272/2008) N,N,N-trimethyl-nitroanilinium chloride would be classified as Category 3 for Oral Acute Toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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