Methacrylaldehyde

Toxicity to other aquatic organisms

Administrative data

Endpoint:

toxicity to other aquatic vertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

publication

Title:

Simultaneous multiple species testing: Acute toxicity of 13 chemicals to 12 diverse freshwater amphebian, fish and invertebrate families

Author:

Holcombe, G. W. et al.

Year:

1987

Bibliographic source:

Arch. Environ. Contam. Toxicol., 16,|697-710

Materials and methods

Test guideline

Guideline:

other: American Society for Testing and Materials, modified

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Acrylaldehyde

EC Number:

203-453-4

EC Name:

Acrylaldehyde

Cas Number:

107-02-8

Molecular formula:

C3H4O

IUPAC Name:

acrylaldehyde

Sampling and analysis

Analytical monitoring:

yes

Test organisms

Test organisms (species):

Xenopus laevis

Details on test organisms:

- Age at study initiation: tadpoles

Study design

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Test conditions

Hardness:

44.7 (40.8 - 47.6) mg/L as CaCO3

Test temperature:

17 °C +- 0.5 °C

pH:

7.39 +- 0.22 (6.84 - 7.80) N = 111

Dissolved oxygen:

8.7 +- 1.1 mg/l (4.8 - 10.7); N=192
The D.O. concentrations were never less than 50% and seldom less than 60% saturation during all tests.

Nominal and measured concentrations:

measured concentrations: 0.005, 0.008, 0.025, 0.068, 0.151 mg/l

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: glass aquaria, 60.0 x 30.0 x 30.0 cm deep, 36.0 to 39.6 L
- Type of flow-through: A modified 2-L proportional diluter (Mount and Brungs 1967) with a dilution factor of 0.5 was used. During each diluter cycle, flow-splitting chambers divided each of five exposure concentrations and a control into duplicate exposure tanks.
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2

TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Lake Superior and heated to the appropriate test temperature.


OTHER TEST CONDITIONS
- Photoperiod: 12h/12h light/dark
- Light intensity: Fluorescent lamps provided a mean light intensity of 17 lumens at the water surface.

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

0.007 mg/L

Basis for effect:

mortality

Remarks on result:

other: 95% CL: 0.006 - 0.008 mg/l

Applicant's summary and conclusion

Executive summary:

The 96h-LC50 of acrolein for tadpoles of Xenopus laevis was 0.007 mg/l. Tadpoles were exposed in a flow through test system.