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Diss Factsheets
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EC number: 308-757-1 | CAS number: 98246-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study under GLP analytical purity not indicated, unclear if dosing refers to product tested or active ingredient.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Hoe: WISKf(SPF71), Hoechst AG, Germany- Age at study initiation: males: ca. 6-7weeksfemales: ca 8 weeks- Weight at study initiation:males: mean = 169 g, SD = 6.41, xmin = 160, xmax = 178, n=10females: mean = 181.5 g, SD = 11.7, xmin = 160, xmax = 199, n=10Randomization: yesAnimal maintenance: in fully air-conditioned rooms in macrolon cages (type 4) on soft wood granulate in groups of 5 animalsRoom temperature: 22 ± 3 °CRelative humidity: 50 ± 20 %Lighting time: 12 hours dailyAcclimatization: at least 5 daysFood:Rattendiat Altromin 1324, (Altromin-GmbH, Lage/Lippe), ad libitumWithdrawal of food: from about 16 hours before to 3 - 4 hours after treatmentWater: tap water in plastic bottles, ad libitumAnimal identification: fur marking with KMnO4 and cage numbering
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- deionized
- Details on oral exposure:
- VEHICLE- Concentration in vehicle: 5 % (500mg/kg bw) 25% (2000 mg/kg bw)- Amount of vehicle (if gavage):MAXIMUM DOSE VOLUME APPLIED: 10 ml (25% solution) = 2000 mg/kg bw
- Doses:
- 500, 1000 mg/kg body weight
- No. of animals per sex per dose:
- 10 (5 males, 5 females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: up to 21 days- Frequency of observations and weighing: daily- Necropsy of survivors performed: yes
- Statistics:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 500 - 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg body weight: 100 % mortality500 mg/kg body weight: 0 % mortality
- Clinical signs:
- Clinical symptoms:- 2000 mg/kg group: flanks drawn-in, decreased spontantenous activity, respiratory sounds, indications of cyanosis, clonic convulsions- 500 mg/kg group: flanks drawn-in, decreased spontaneous activity, squatting posture, salivation (from day 2 p.a. free of symptoms)
- Body weight:
- Body weight development generally not influenced
- Gross pathology:
- The macroscopic examination of deceased male and female animals revealed the following features: - Small intestine filled with clear liquid - Small intestinal mucosa reddened - Pancreas reddened - Adrenal dark discolored - Liver dark discolored - Foam in the lung The animals killed at the end of follow-up period were free of macroscopically visible alterations.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The LD 50 is between 500 and 2000 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test item was investigated in groups of 5 male and 5 female Wistar rats each at dose levels of 500 and 2000 mg/kg body weight according to OECD TG 401. The animals rceived the compound in water as vehicle via gavage. The observation period following treatment in the 500 mg/kg group was up to 21 days. Most animals treated at 2000 mg/kg died within 10 minutes after application. One female and one male died 2 and 3 hours p.a. respectively. No mortality occurred in the 500 mg/kg group.Clinical symptoms included hypoactivity, squatting posture and salivation. In the 2000 mg/kg group additionally indications of cyanosis and clonic convulsions were observed shortly before the animals died. Macroscopically a discolouration of the liver, reddenings of the pancreas and the intestinal mucosa, as well as foam in the lungs. Based on the study results, the median lethal dose (LD50) was between 500 and 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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