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EC number: 223-804-5 | CAS number: 4079-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Sep 1989 to 27 Sep 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 L.11
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in studyreport): Golpanol DEP
- Batch No.: 1/89 - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION OF TEST SOLUTIONS
Test concentrations were prepared as dilutions from a 2000 mg/L stock solution. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Supplier: Bundesgesundheitsamt, Berlln
- Breeder: Dr.U.Noack-Laboratorium, Hildesheim
CULTURING
- Feed: Fresh algal mass (Scenedesmus subspicatus) was given once a day.
- Rearing: Single breed in 100 mL beaker with 60 mL breeding water.
- Water change: Water was changed three times per week (monday, wedenesday and friday).
- Temperature: 21 °C
- Ca/Mg ratio: 5:1
- Na/K ratio: 20:1
- Conductivity: 658 µS/cm
- Reproduction rate: 8 animals per day - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21.0 °C
- pH:
- 7.58 - 9.03. See 'Any other information on materials and methods incl. tables'
- Dissolved oxygen:
- 8.4 - 8.5 mg O2/L
- Conductivity:
- 658 µS/cm
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control), 32, 58, 100, 180, 320, 580 and 580 (neutralised pH) mg/L (based on a range-finding study).
- Measured concentrations: not determined. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Tall beakers with a nominal volume of 50 mL, containing 20 mL of a given test item concentration (DIN 12 331)
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: According to DIN 38412 part 11, 8.2
- Culture medium different from test medium: No
- Oxygen measurement: oxygen was measured using Oximeter, Oxi 191, Fa. WTW
- pH measurement: pH was measured using Oximeter, Oxi 191, Fa. WTW
- Temperature measurement: Temperature was measured using Oxi 191
- Conductivity: 658 µS/cm
- Ca/mg ratio: 5:1
- Na/K ratio: 20:1
OTHER TEST CONDITIONS
- Light intensity: 10 µE/qm X S
EFFECT PARAMETERS MEASURED: Immobility was determined after 3, 6, 24 and 48 hours exposure.
RANGE-FINDING STUDY
- Test concentrations: 0.1, 1, 10, 50, 100 and 500 mg/L.
- Results used to determine the conditions for the definitive study: At study termination after 48 hours, all test animals in the group exposed to the highest concentration died (10/10). In the 100 mg/L group only one animal died after 48 hours exposure. No mortality was observed in the lower concentrations. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 129 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% C.I.: 109 - 152 mg/L
- Details on results:
- During exposure, no immobilisation was observed in the control. In the 32, 58, 100, 180, 320, 580 and 580 (neutralised pH) mg/L test groups, the immobilisation was 5, 10, 30, 75 and 100, 100 and 80%, respectively. A dose-dependent increase in immobility was observed with increasing test substance concentrations. An overview of the results is provided in 'Any other information on results incl. tables'.
- Results with reference substance (positive control):
- The test with the reference material potassium dichromate was performed from 26 Sep, 1989 to 27 Sep, 1989. The 24-h EC50 of the reference substance was determiend to be 0.9 mg/L.
- Reported statistics and error estimates:
- Spearman-Kärber method was used.
- Validity criteria fulfilled:
- yes
- Remarks:
- See 'Any other information on materials and methods incl. tables'
Reference
Table: Immobility observed throughout the study
Immobility [%] |
||||||||||||||||||||
Test concentration [mg/L] |
3h |
6 h |
24 h |
48 h |
||||||||||||||||
R1 |
R2 |
R3 |
R4 |
mean |
R1 |
R2 |
R3 |
R4 |
mean |
R1 |
R2 |
R3 |
R4 |
mean |
R1 |
R2 |
R3 |
R4 |
mean |
|
580 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
320 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
5 |
20 |
20 |
20 |
60 |
35 |
100 |
100 |
100 |
100 |
100 |
180 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
100 |
80 |
80 |
40 |
75 |
100 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
20 |
10 |
0 |
0 |
20 |
20 |
10 |
0 |
40 |
40 |
40 |
30 |
58 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
20 |
0 |
0 |
10 |
32 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
5 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
580 (pH neutralised) |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
5 |
100 |
60 |
100 |
60 |
80 |
ADDITIONAL EFFECT VALUES
3-h EC50: 450 mg/L (95% C.I.: 320 - 580 mg/L)
6-h EC50: 400 mg/L (95% C.I.: 320 - 580 mg/L)
24-h EC50: 352 mg/L (95% C.I.: 310 - 399 mg/L)
3-h EC0: 320 mg/L
6-h EC0: 320 mg/L
24-h EC0: 180 mg/L
48-h EC0: 58 mg/L
3-h EC100: 580 mg/L
6-h EC100: 580 mg/L
24-h EC100: 580 mg/L
48-h EC100: 320 mg/L
Description of key information
The 48-h EC50 value is 129 mg/L in aquatic invertebrates (Daphnia magna).
Key value for chemical safety assessment
Additional information
The acute toxicity to aquatic invertebrates was determined in a study according to DIN 38412 L.11 (GLP not specified) (Dr. Noack Laboratorium, 1989). In this study, daphnids (D. magna, 20 per concentration) were exposed to nominal concentrations of 0 (control), 32, 58, 100, 180, 320, 580 and 580 (neutralised pH) mg/L for 48 hours under static conditions. As no analytical confirmation of the test concentrations was performed, the effect values were are expressed as nominal. Immobilization was recorded after 3, 6, 24 and 48 hours exposure. Throughout the study and at study termination, no immobilization was observed in the control treatment. Immobility recorded after 48 hours exposure increased with increasing test substance concentration from 5% in the lowest concentration treatment (32 mg/L) up to 100% immobilization in the highest concentration treatment (580 mg/L). Based on these findings, the 48-h EC50 value was determined at 129 mg/L.
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