Bis(5-oxo-L-prolinato-N1,O2)copper

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

other: expert statement

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: expert statement

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1996

Reference 2

Reference Type:

publication

Title:

Effect of copper on nitrifying and heterotrophic populations in activated sludge

Author:

Song J., Cha D., Allen H., Son A., Choe J.

Year:

2002

Bibliographic source:

Proceedings of the Water Environment Federation, WEFTEC 2002: Session 41 through Session 50, pp. 357-366(10).

Reference 3

Reference Type:

study report

Title:

Unnamed

Year:

2005

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Litterature review.
Estimation of the Cu2+ inhibitory activity towards STP microbes as a worst-case estimation of the test item ready biodegradability.
see more details under results.

GLP compliance:

no

Remarks:

not applicable to expert statement

Test material

Test material information

Constituent 1

Reference substance name:

Bis(5-oxo-L-prolinato-N1,O2)copper

EC Number:

239-471-4

EC Name:

Bis(5-oxo-L-prolinato-N1,O2)copper

Cas Number:

15454-74-7

Molecular formula:

C10H12CuN2O6

IUPAC Name:

bis(5-oxo-L-prolinato-N1,O2)copper

Specific details on test material used for the study:

not applicable to expert statement

Study design

Inoculum or test system:

other: not applicable to expert statement

Results and discussion

% Degradation

Key result

Parameter:

probability of ready biodegradability (QSAR/QSPR)

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Remarks:

see results

Details on results:

see below

Any other information on results incl. tables

The test item consists in an organic part (L-pidolic acid, CAS 98 -79 -3) and the Cu2 + ion. The organic part L-Pidolic acid is readily biodegradable (lead registrant proprietary data: Barthel Y, 2005). But the Cu2+ ion has a strong inhibitory activity towards microbe activity, as reflected in Madoni et al. (1996) and Song et al. (2002) publications.

The Cu2+ supply at the recommended dose-level of a biodegradation test on Copper Pidolate (CuPCA), 100 mg/L according to OECD 301, would be: 100*MW(Cu)/MW(CuPCA)= 100*63.55/319.76 = 19.9 mg/L.

This is largely above all Cu2+ concentrations reported as inhibitory to microbes in the two publications.

Therefore, as a worst-case the test item is considered as non-readily biodegradable without need for testing.

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Interpretation of results:

not readily biodegradable

Conclusions:

As a worst-case the test item is considered as non-readily biodegradable without need for testing.