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EC number: 218-507-2 | CAS number: 2167-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Start of the study: 9 May 1979 End of the study: 14 June 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Trigonox D-B50 was dispersed to a fine mist by means of a stainless steel/glass aerodynamic nozzle nebulizer. The nebulizer was provided with a baffle in order to remove the larger droplets from
the mist produced. The mist was passed through the exposure chamber with a total airflow of 1.6 m^3/h for Trigonox D-B 50. - GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- Di-tert-butyl sec-butylidene diperoxide
- EC Number:
- 218-507-2
- EC Name:
- Di-tert-butyl sec-butylidene diperoxide
- Cas Number:
- 2167-23-9
- Molecular formula:
- C12H26O4
- IUPAC Name:
- 2,2-bis(tert-butylperoxy)butane
- Reference substance name:
- Dibutyl phthalate
- EC Number:
- 201-557-4
- EC Name:
- Dibutyl phthalate
- Cas Number:
- 84-74-2
- Molecular formula:
- C16H22O4
- IUPAC Name:
- dibutyl phthalate
- Reference substance name:
- Butanone
- EC Number:
- 201-159-0
- EC Name:
- Butanone
- Cas Number:
- 78-93-3
- Molecular formula:
- C4H8O
- IUPAC Name:
- butan-2-one
- Test material form:
- liquid
Constituent 1
additive 1
Constituent 2
- Specific details on test material used for the study:
- Samples of the test materials were received from the principal on 9 April 1979. Trigonox D-B50 is also a clear, colourless liquid with the following composition:
49-51 % 2.2 -Di-tert-butylperoxy butane
51-49 % Dibutyl phthalate
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Fifty male and fifty female SPF-reared rats (Cpb; WU, Wistar Random) were obtained from the Central Institute for the Breeding of Laboratory Animals TNO, Zeist, The Netherlands. At the beginning of the study the mean body weight of the males was 180 g and that of the females 135 g.
During the 2-week observation period foll owing the exposure the animals were kept in stainless steel cages (5 to a cage), which were suspended in an open rack in an animal room. They received ad libitum the Institute's stock diet for rats and bottled unfluoridated water. However, during exposure the animals had no access to water and food.
The temperature and the relative humidity in the animal room were 21±1°C and 50 - 60 per cent respectively; they were automatically controlled.
Exposure chamber:
A stainless steel exposure chamber, having a capacity of 1.5 m^3 was used. The rats were kept individually during the exposure in wire-screen cages to prevent crowding and minimize filtration of inspired air by the animals' fur. They could be continuously observed through the hard glass entrance door of the chamber.
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Trigonox D-B 50 was dispersed to a fine mist by means of a stainless steel/glass aerodynamic nozzle nebulizer. The nebulizer was provided with a baffle in order to remove the larger droplets from
the mist produced. The mist was passed through the exposure chamber with a total airflow of 1.6 m^3/h for Trigonox D-B 50. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- The maximum attainable concentration of the Trigonox D-B 50 aerosol in the test atmosphere turned out to be 2.42 g/m^3 air.
- No. of animals per sex per dose:
- 5 animals per sex per dose.
- Control animals:
- no
- Details on study design:
- Analysis:
Analysis of the test atmosphere of Trigonox D-B 50 was performed gravimetrically. Samples of the atmosphere was taken by passing a measured quantity of the test atmosphere through a Cambridge glassfibre filter at intervals of about 1.5 hour. Particle size determinations and counts were carried out in samples taken from the atmosphere in the chamber with a Cascade Impactor.
Conduct of the study:
Five males and five females were exposed to the test material for 4 hours. After the exposure period the animals were returned to their living cages for an observation period of 2 weeks. During the 2-week observation period the body weight of the animals was frequently recorded.
Calculation of the LC50-values:
If applicable, the four-hour LC50 was calculated according to the method of Litchfield and Wilcoxon (1949).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2.42 other: g/m^3 air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occurred during the 4-hour exposure period and the subsequent observation period of 14 days.
- Body weight:
- The males and females gained weight in a normal way during the 14-day observation period.
Any other information on results incl. tables
The maximum attainable concentration of the Trigonox D-B 50 aerosol in the test atmosphere turned out to be 2.42 g/m3 air.
Droplet size determinations in impaction samples revealed a maximum droplet diameter of 6.7 μm. Ninety per cent of the mist consisted o.f droplets with a diameter of 1.2-3.3 μm.
No information on the behaviour of the rats during the exposure is available, because the animals were completely invisible as a consequence of the dense mist prevailing in the inhalation chamber. No mortality occurred during the 4-hour exposure period and the subsequent observation period of 14 days.
The males and females gained weight in a normal way during the 14-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From the results of the present acute inhalation toxicity studies it is concluded that:
the 4-hour LC50 of Trigonox D-B 50 in rats is higher than 2.42 g/m^3 air. - Executive summary:
1. The acute inhalation toxicity of curing agent, Trigonox D-B 50, was studied separately by exposing rats one single time for 4 hours to atmospheres containing aerosols
of each of the various substances.
2. Exposure to Trigonox D-B 50 at the maximum attainable concentration of 2.42 g/m3 air did not result in mortality or any sign of intoxication. It was concluded that the
4-hour LC50 of Trigonox D-B 50 in rats was higher than 2.42 g/m3 air.
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