Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-030-7 | CAS number: 7783-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assesment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Ferric phosphate- Toxicological evaluation
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 013
- Bibliographic source:
- Ferric phosphate - RAR - Vol. 3, 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EC Commission Directive 92/69/EEC, Method B5, Acute Toxicity – Eye irritation
- Principles of method if other than guideline:
- To assess the extent of ocular damage caused by Ferric phosphate in rabbit eyes
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iron orthophosphate
- EC Number:
- 233-149-7
- EC Name:
- Iron orthophosphate
- Cas Number:
- 10045-86-0
- Molecular formula:
- Fe.H3O4P
- IUPAC Name:
- Ferric phosphate
- Test material form:
- solid: crystalline
- Details on test material:
- Name of the test compound: Ferric orthophosphate
Molecular formula: FePO4
Molecular weight: 154 g/mo/l
Substance type: Inorganic
Physical State: Solid
Lot/Batch no.: 105668
Purity: Minimum 24.8 % Fe
Stability of test compound: Stable under recommended storage conditions (room temp. in the dark)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Sex: Male
- Source: Charles River UK, Margate, Kent, England
- Age at study initiation: 9 - 11 weeks old at time of dosing
- Weight at study initiation: 1344 – 1935 g (males)
- Fasting period before study: no data available
- Housing: Individually in standard laboratory rabbit housing units
- Diet (e.g. ad libitum): Charles River Breeding and Maintenance Diet for Rabbits, ad libitum
- Water (e.g. ad libitum): Ad libitum access to automated watering system supplied with tap water
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 °C
- Humidity (%):55 ± 15 %
- Air changes (per hr): 15 per hour
- Photoperiod (hrs dark / hrs light): Alternating 12 hour light/dark cycle
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 3.2 mg equivalent to a volume of 0.1 mL
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- The treated eyes were assessed at 1, 24, 48 and 72 hours post-instillation and reactions were graded using the standard Draize scale for ocular reactions
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 3 male rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not washed
- Time after start of exposure: no data available
SCORING SYSTEM: The treated eyes were assessed at 1, 24, 48 and 72 hours post-instillation and reactions were graded using the standard Draize scale for ocular reactions
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein: no data available
Other information: After instillation of the test substance, ocular assessments and clinical observations were performed in the treated eyes for up to 72 hours. Mortality and clinical condition was checked twice daily and rabbits were checked at least once daily for signs of systemic toxicity. Body weights were recorded on the day prior to instillation of ferric phosphate.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.44
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of systemic toxicity or clinical reaction to treatment were observed. No deaths occurred.
The reactions elicited included iridial and conjunctival changes, generally very slight but including slight chemosis in one rabbit. No corneal opacity was evident and all of the ocular
changes had overtly resolved within 48 -72 hours of dosing.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The reactions elicited included iridial and conjunctival changes, generally very slight
but including slight chemosis in one rabbit. No corneal opacity was evident and all of the ocular changes had overtly resolved within 48 -72 hours of dosing. The mean scores for the group of three rabbits over the 24 - 72 hour assessments were 0,0,0,0.44,0 for corneal opacity, iridial response, conjunctival redness, and conjunctival chemosis respectively.
Based on the scores and reversible reactions, ferric phosphate can be considered to be not irritating to rabbit eyes. - Executive summary:
The ocular irritation potential of the test chemical was assessed in rabbits. The study was performed according to OECD 405 and EC Commission Directive 92/69/EEC, Method B5, Acute Toxicity – Eye irritation Guidelines.3.2 mg equivalent to a volume of 0.1 mL of undiluted test chemical was instilled into the eyes of 3 male New Zealand White rabbits.After instillation of the test substance, ocular assessments and clinical observations were performed in the treated eyes for up to 72 hours. Mortality and clinical condition was checked twice daily and rabbits were checked at least once daily for signs of systemic toxicity. Body weights were recorded on the day prior to instillation of test chemical. The treated eyes were assessed at 1, 24, 48 and 72 hours post-instillation and reactions were graded using the standard Draize scale for ocular reactions
The reactions elicited included iridial and conjunctival changes, generally very slight but including slight chemosis in one rabbit. No corneal opacity was evident and all of the ocular changes had overtly resolved within 48 -72 hours of dosing. The mean scores for the group of three rabbits over the 24 - 72 hour assessments were 0,0,0,0.44,0 for corneal opacity, iridial response, conjunctival redness, and conjunctival chemosis respectively.
Based on the scores and reversible reactions, the test chemical can be considered to be not irritating to rabbit eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.