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EC number: 614-345-5
CAS number: 68155-40-8
Ecotoxicity testing with cationic surfactants
is complicated as these substances tend to sorb to negatively charged
surfaces like glassware and test organisms. The reproducibility of these
tests is in general poor. When cationic surfactants enter the
environment they will be immediately sorbed to the suspended matter and
DOC present in the environment. The toxicity will due to this sorption
be mitigated. The degree of this mitigation is however poorly predicted
with the currently available exposure models (e.g. EUSES) as they only
predict sorption based on hydrophobic interaction with organic matter
where the main sorption of these substances will be due to ionic
interaction. To increase the reproducibility of the ecotoxicity testing
and to compensate for the deficiency of the bioavailability modeling
tests have been performed with river water. To ensure the
representativeness of the test results, realistic worst-case river water
(DOC close to 3 mg/L and suspended matter close to 15 mg/L) has been
used. These river water studies should therefore be considered as higher
tier studies. This approach is also applied in EU risk assessments of
DODMAC and primary fatty amines and is known as the Bulk-approach
(ECETOC TR88 2003).
In order to classify a standard laboratory
toxicity study as valid, it is of particular importance that - besides
information on test substance, test method / conditions and test
organism used - suitable precautions are taken to prevent the loss of
test substance by adsorption and that exposure concentrations are based
upon measured levels.
For ecotoxicity tests performed using the bulk-approach,
however, adsorption to suspended matter and DOC is acceptable and only
adsorption to glassware should be accounted for. For a valid bulk
approach test the concentration-effect relationship should be based on
the sum of adsorbed and dissolved substance in the volume of the medium
tested. One of the advantages of the bulk approach tests with these
difficult substances is that in the presence of suspended matter, humic
acids and/or algae, the residual sorption to glassware will be
negligible. The results of these bulk approach tests are therefore much
easier to interpret, more environmental realistic, and when compared to
PECbulkclearly provide a more appropriate assessment of risks
for the environment. All effect values given are therefore based on the
nominal test item concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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