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EC number: 700-748-4
CAS number: 1226911-69-8
times of the dead time
Retention Time (mins)
Mean Retention Time (mins)
times, capacity factors (k') and log10Koc values for the reference
Capacity Factor (k')
5.4.1/4: Adsorption coefficient of the sample
Mean Log10 Koc
test item contains no functional groups which would dissociate in the
normal environmental pH range (approximately pH 5.5 to pH 7.5);
therefore testing was performed without adjusting the pH of the mobile
the slope of the calibration curve for the reference standards showed
good first order correlation and as the retention times between
duplicate injections for each solution was consistent, the HPLC method
was considered valid for the determination of adsorption coefficient.
Based on the chromatographic data, the test item was considered to be
stable during the test procedure.
adsorption coefficient (Koc) for the test substance was determined using
an HPLC screening method according to OECD 121 guideline with GLP
test system utilized a high performance liquid chromatograph and a
cyanopropyl reverse phase HPLC column containing lipophilic and polar
moieties. The column temperature of 30 °C with a mobile phase consisting
of 55 % methanol and 45 % water. A 119 mg/L sample of the test substance
using HPLC method. Calibrations were performed using 12 reference items;
retention times, capacity factors (k') and log10Koc values for the
reference standards were determined at a constant HPLC column
temperature of 30 °C. Dead time of the HPLC-system was determined with
Formamide. The retention times, capacity factor and log10 Koc value
determined for the test substance at a constant HPLC column temperature
of 30 °C.
adsorption coefficient (Koc) of the test item has been determined to be
719, log10 Koc 2.86.
OECD Guideline 121, EU Method C.19, GLP, key study, validity 1:
log Koc = 2.86
Koc = 719
The mobility of the substance is considered as low (according to the
criteria developed by P.J. McCall et al., 1981).
To assess the adsorption potential of the registered substance on soil
and on sewage sludge, one key study is available.
This study (WIL, 2015) was performed on the registered substance
according to OECD Guideline 121 and EU Method C.19 (HPLC screening
method) under GLP conditions. According to this study, the adsorption
coefficient log Koc of the registered substance was determined at 2.86.
The results indicate that the substance has low mobility (according to
P.J. McCall et al., 1981).
1McCall P.J., Laskowski D.A., Swann R.L., and Dishburger H.J., (1981),
“Measurement of sorption coefficients of organic chemicals and their
use, in environmental fate analysis”, in Test Protocols for
Environmental Fate and Movement of Toxicants. Proceedings of AOAC
Symposium, AOAC, Washington DC.
Mobility classification scheme:
0 - 50
50 - 150
150 - 500
500 - 2000
2000 - 5000
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