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EC number: 700-748-4
CAS number: 1226911-69-8
study was performed similar to OECD Guideline No. 111. The aim of the
study is to assess the stability of the substance in a series of simple
media simulating perfumery applications. The test media are standard
aqueous buffers at pH 2, pH 5, pH 7, pH 8.5 and pH 12 containing 1% of
non ionic surfactant (Arkopal N 150). The tests are done in accelerated
conditions at 40 °C during 28 days.
– 300 ppm of raw material are dissolved in the pH buffer containing the
surfactant (Arkopal N 150) and put into storage in an oven at 40°C.
Small aliquots of the test solution are extracted with an organic
solvent (typically cyclohexane or ethyl acetate) containing a
hydrocarbon standard (typically C12, C17 or C20) on a regular basis
throughout the test (typically at time = 0, 0.25, 1, 2, 4, 7, 15, 21 and
28 days). The extracts are analyzed by GC-FID and the results are
plotted as (Area/Area Std) expressed in [%]. The measurement at time = 0
is set at 100% and the succeeding measurements are calculated relatively
to the time = 0 measurement. Therefore the curves represent the
percentage of product remaining in the test solution at the time of
disappearance of the parent compound after 28
days at 40 °C is circa 70%
at pH 2, less than 5%
at pH 5, circa 31% at pH 7
and circa 70% at pH
8.5, and 100% disappearance at pH 12.
the registered substance is not readily biodegradable, a GLP hydrolysis
study does need to be conducted, in accordance with REACH Annex VIII
column 2. One study was available:
non-GLP stability test was performed on the registered substance with a
method similar to OECD Guideline No. 111, in accelerated conditions at
40 °C during 28 days. The disappearance of the substance after 28 days
at 40 °C and at environmentally relevant pH (comprised between 5 and
8.5) is comprised between less than 5% and 70%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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