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Diss Factsheets
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EC number: 401-100-0 | CAS number: 109037-78-7 TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Information from migrated NONS file, as per inquiry number 06-2120053135-66-0000, permission to refer granted by ECHA
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Maximisation test)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Information from migrated NONS file
- Species:
- guinea pig
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
a) 0.5% v/v in acetone containing 5% w/v alembicol D
b) Undiluted
Concentration of test material and vehicle used for each challenge:
20% and 50% v/v in acetone - Concentration / amount:
- Concentration of test material and vehicle used at induction:
a) 0.5% v/v in acetone containing 5% w/v alembicol D
b) Undiluted
Concentration of test material and vehicle used for each challenge:
20% and 50% v/v in acetone - No. of animals per dose:
- Number of animals in test group: 20
Number of animals in negative control group: 20 - Positive control results:
- Evidence of sensitisation of each challenge concentration: Evidence of sensitisation was observed in 3 animals.
- Key result
- Reading:
- other: Not available - summary provided by ECHA 2014
- Group:
- test chemical
- Dose level:
- 20% and 50%
- No. with + reactions:
- 3
- Total no. in group:
- 20
- Clinical observations:
- Evidence of sensitization at each concentration.
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- other: Not available - summary provided by ECHA 2014
- Group:
- negative control
- Dose level:
- 20% and 50% v/v
- Total no. in group:
- 20
- Clinical observations:
- Not available - summary provided by ECHA 2014
- Remarks on result:
- other: Not available - summary provided by ECHA 2014
- Key result
- Reading:
- other: Not available - summary provided by ECHA 2014
- Group:
- positive control
- Dose level:
- Not available - summary provided by ECHA 2014
- Clinical observations:
- Not available - summary provided by ECHA 2014
- Remarks on result:
- other: Not available - summary provided by ECHA 2014
- Interpretation of results:
- other: not classified
Reference
Evidence of sensitisation of each challenge concentration: Evidence of sensitisation was observed in 3 animals.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.