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EC number: 445-890-5 | CAS number: 201290-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key 28-day repeated dose oral toxicity study, conducted according to OECD 407 and GLP, the reported NOAEL value was 150 mg/kg bw/day based on post-dose clinical signs in both sexes and reduced motor activity seen in females dosed at 650 mg/kg bw/day (Huntingdon, 2003).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 150 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key 28-day repeated dose oral toxicity study, conducted according to OECD 407 and GLP, the reported NOAEL value was 150 mg/kg bw/day post-dose clinical signs in both sexes and the reduced motor activity seen in females dosed at 650 mg/kg bw/day (Huntingdon, 2003).
Following daily oral gavage administration of 15, 150 and 650 mg/kg bw/day of test substance in dry corn oil for 28 days to three groups of 5 male and 5 female rats, no mortality occurred during the study period. Reduced body tone, abnormal gait, underactivity, limited use of limbs, hunched posture, pre and post-dose salivation, unresponsive behaviour and partially closed eyelids were observed in animals dosed at 650 mg/kg bw/day. Each day the animals fully recovered from the post-dose clinical signs. Neurobehavioural screening revealed lower motor activity in females dosed at 650 mg/kg bw/day. The lower motor activity in females was considered to be likely associated with the post-dose reduced body tone and abnormal gait. The post-dose clinical signs in both sexes and the lower motor activity seen in females were considered to represent toxicity, likely to be associated with a transient effect on the nervous system.
No treatment-related effects were observed on body weights. The overall mean food consumption for females at 650 mg/kg bw/day was lower than the control. Food efficiency values for all treated animals were comparable to the controls.
The microscopic examinations revealed treatment-related hyaline droplets in the kidneys of most of the treated males. These lesions were considered to be associated with the slightly higher than control mean creatinine levels seen for all treated male groups. Dose-response relationship was seen in the increased creatinine levels, however the magnitude of the differences were minimal and considered not to be of toxicological importance. The presence of hyaline droplets in the cortical tubule cells of the kidneys in male rats is likely to have occurred by the hydrocarbon based origin of the test material. Similar effects due to hydrocarbons have not been shown to occur in human kidneys, nor in female rats. Therefore, the incidence of these findings were considered to be attributable to treatment, but of no toxicological importance with regard to health risk to humans.
Lower platelet count and higher aspartate aminotransferase values were observed in males dosed at 650 mg/kg bw/day when compared to controls. These differences from control were slight and although possibly related to treatment, were not associated with any corroborative findings including histopathological lesions. Therefore, the changes in platelet and aspartate aminotransferase values noted in males dosed at 650 mg/kg bw/day were considered to be of no toxicological importance.
Justification for classification or non-classification
Based on the available data for N,N-bis(trimethylsilyl)aminopropylmethyldiethoxysilane, no classification is required for specific organ toxicity following repeated exposures according to Regulation (EC) No. 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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