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Diss Factsheets
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EC number: 202-440-0 | CAS number: 95-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1947
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given but sufficient to establish reliability as a supporting study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 947
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The toxic effects of Xylidine were studied in dogs and cats following cutaneous application. An area of the backs of the animals was clipped and measured quantities of the chemical were spread on 2 1/4 by 3 1/2 inch gauze pads applied to the clipped areas, strapped to body with adhesive tape, covered with tinfoil which was fixed with gauze bandages, and the entire body was covered with a tightly fitting jacket, so that the animals were unable to interfere with the application. The material was left on the skin for 23 - 24 h and blood was tested for methemoglobine at intervals of 2.5 , 5, 7.5, 10 h.
- GLP compliance:
- no
- Remarks:
- study performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Xylidine
- EC Number:
- 215-091-4
- EC Name:
- Xylidine
- Cas Number:
- 1300-73-8
- IUPAC Name:
- 2,3-dimethylaniline
- Details on test material:
- Xylidine, Isomeric ratio and composition not defined.
Constituent 1
Test animals
- Species:
- other: dogs and cats
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Please refer to "Details on study design"
- Duration of exposure:
- 23 -24 h
- Doses:
- 500 and 2000 mg/kg for dogs, 1000 mg/kg for cats
- No. of animals per sex per dose:
- 2 dogs, 4 cats
- Control animals:
- not specified
- Details on study design:
- The toxic effects of Xylidine were studied in dogs and cats following cutaneous application. An area of the backs of the animals was clipped and measured quantities of the chemical were spread on 2 1/4 by 3 1/2 inch gauze pads applied to the clipped areas, strapped to body with adhesive tape, covered with tinfoil which was fixed with gauze bandages, and the entire body was covered with a tightly fitting jacket, so that the animals were unable to interfere with the application. The material was left on the skin for 23 - 24 h and th blood was tested for methemoglobine at intervals of 2.5 , 5, 7.5, 10 h.
- Statistics:
- None
Results and discussion
- Preliminary study:
- no data
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: dog
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: cat
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Remarks on result:
- other: dog, 24 h exposure
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 2 000 mg/kg bw
- Remarks on result:
- other: cat, 24 h exposure
- Mortality:
- Please refer to "Executive summary"
- Clinical signs:
- other: Please refer to "Executive summary"
- Gross pathology:
- No data
- Other findings:
- Please refer to "Executive summary"
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the reported effects/mortality the dermal LD50 (dog, 24 h exposure) is set at > 2000 mg/kg bw/d and the dermal LD50 (24 h exposure, cat) is considered to be < 2000 mg/kg bw/d.
Classification: Xn, R21; H302 - Harmful in contact with skin - Executive summary:
With xylidine the methemoglobine formation is slow or very moderate. The administration of 500 mg/kg caused only some vomiting after 2 h and moderate irritation of the skin although in one instance the jacket was left on for 48 h. With the application of 2000 mg/kg for 24 h one dog vomited after 2 h and both dogs developed muscular weakness but recovered after 9 h had elapsed and were apparently normal the next day. Xylidine with respect to methemoglobinemic action is less toxic than aniline, but definitely toxic.
2000 mg/kg Xylidine applied to the skin of cats over a period of 24 h are definitely toxic and produce marked methemoglobinemia and delayed death 24 to 76 h after discontinuation of experiment. Cats treated with xylidine developed early weakness and staggering gait ans lost their appetite, they recovered temporarily to a moderate extent after discontinuation of the exposure. However during subsequent days they became more and more comatoso until they died.
Classification: Xn, R21; H302 - Harmful in contact with skin
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