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Diss Factsheets
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EC number: 206-108-6 | CAS number: 301-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see "read-across statement"
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- not specified
- Duration:
- 3 wk
- Dose descriptor:
- EC50
- Effect conc.:
- 1 500 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Basis for effect:
- reproduction
- Duration:
- 3 wk
- Dose descriptor:
- LC50
- Effect conc.:
- 42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Basis for effect:
- mortality
- Duration:
- 3 wk
- Dose descriptor:
- LOEC
- Effect conc.:
- 350 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Basis for effect:
- reproduction
- Details on results:
- The 16% reproductive impairment concentration was taken as LOEC since it represented the minimal reproducible value below which no difference in the variability in reproduction could be detected in concentrations and controls.
- Reported statistics and error estimates:
- Results were said to be statistically evaluated with the method of Litchfield and Wilcoxon (1949) for establishing approximations of the 95% CI for survival. Reproductive effects were analysed in a similar manner excluding CIs. Reproductive effects are given in terms of reproductive impairment by percentage.
- Validity criteria fulfilled:
- not applicable
- Remarks:
- Details on mortality and mean number of live offspring of the parent animals in the controls not given
- Conclusions:
- Older study with some data gaps but considered useful for PNEC derivation in the EU risk assessment (ECB 2008)
- Executive summary:
Study reporting on short term and long term toxicity of tin to Daphnia magna. Tests not done according to standard protocol, but of sufficient quality and considered useful for setting the PNEC freshwater. Study used for that purpose in the EU risk assessment process on tin (ECB 2008). Culture medium, test water conditions well described. Referred to the target substance the LOEC is 1.194 mg/L.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to section 13 'Analogue Approach Rationale'
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 43.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- not determinable
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 18.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 32.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Conclusions:
- Half lethal concentration (LC50) of parent Daphnia magna exposed for 21 days is not be determined(LC50: >100 mg/L (95% confidence interval: not calculated). The 50% reproductive inhibitory concentration (EC50) of the exposure for 21 days is: 43.3 mg/L (95% confidence interval: 39.4-48.0 mg/L). The maximum no effect concentration (N0EC) and minimum no effect concentration (LOEC) of 21-day exposure on the cumulative number of litters per parent Daphnia magna is as follow: NOEC: 18.0 mg/L. LOEC: 32.0 mg/L
- Executive summary:
Reproductive Inhibition Test of Sodium 2-Ethylhexanoate against Daphnia magna study is done under GLP condition. Animals were exposed total 21days in semi-static water flow system for concentrations: 10.0, 18.0, 32.0, 56.0, 100 mg/L. Half lethal concentration (LC50) of parent Daphnia magna exposed for 21 days is not be determined(LC50: >100 mg/L (95% confidence interval: not calculated). The 50% reproductive inhibitory concentration (EC50) of the exposure for 21 days is: 43.3 mg/L (95% confidence interval: 39.4-48.0 mg/L). The maximum no effect concentration (N0EC) and minimum no effect concentration (LOEC) of 21-day exposure on the cumulative number of litters per parent Daphnia magna is as follow: NOEC: 18.0 mg/L. LOEC: 32.0 mg/L
Referenceopen allclose all
Description of key information
Long-term toxicity to aquatic invertebrate studies with sodium bis(2-ethylhexanoate) and with SnCl2 are available:
Read-across with sodium bis(2-ethylhexanoate), OECD 211, Daphnia magna, semi-static, NOEC(21d) 18.0 mg/L.
Read-across with SnCl2, LOEC 350 µg/L Sn, Referred to the target substance the LOEC is 1.194 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 1.194 mg/L
Additional information
Reproductive Inhibition Test of Sodium 2-Ethylhexanoate against Daphnia magna study is done under GLP condition. Animals were exposed total 21days in semi-static water flow system for concentrations: 10.0, 18.0, 32.0, 56.0, 100 mg/L. Half lethal concentration (LC50) of parent Daphnia magna exposed for 21 days is not be determined(LC50: >100 mg/L (95% confidence interval: not calculated). The 50% reproductive inhibitory concentration (EC50) of the exposure for 21 days is: 43.3 mg/L (95% confidence interval: 39.4-48.0 mg/L). The maximum no effect concentration (N0EC) and minimum no effect concentration (LOEC) of 21-day exposure on the cumulative number of litters per parent Daphnia magna is as follow: NOEC: 18.0 mg/L. LOEC: 32.0 mg/L
Study reporting on short term and long term toxicity of tin to Daphnia magna. Tests not done according to standard protocol, but of sufficient quality and considered useful for setting the PNEC freshwater. Study used for that purpose in the EU risk assessment process on tin (ECB 2008). Culture medium, test water conditions well described. Referred to the target substance the LOEC is 1.194 mg/L.
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