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EC number: 619-290-0 | CAS number: 97780-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Study type:
- direct photolysis
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 316 (Phototransformation of Chemicals in Water - Direct Photolysis)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA OPPTS 835.2240
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 002
- Cas Number:
- 97780-06-8
- Test material form:
- solid
- Details on test material:
- Purity: 98.9%
Constituent 1
Study design
- Radiolabelling:
- yes
- Remarks:
- [Phenyl(U) label-14C] and [Triazine(U) label-14C]
- Analytical method:
- high-performance liquid chromatography
- Buffers:
- pH 7 buffer solution
- Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- > 280
Duration of test at given test condition
- Duration:
- 21 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.28 other: µg/mL
- Reference substance:
- yes
- Remarks:
- Unlabeled test substance
- Dark controls:
- yes
Results and discussion
- Transformation products:
- no
- Remarks:
- No degradation products were found above 5% of the total peak area in either the dark, or irradiated samples.
- Details on results:
- The mean recoveries of the dark control samples over 9 post 0-time sampling intervals (days 1-21) ranged from 99.3% to 101.0% AR. The overall mean recovery in the dark samples was 99.9% AR.
The mean recovery of radioactivity of the irradiated samples over 9 post 0-time sampling intervals (days 1-21) ranged from 100.4% to 110.4% AR. The overall mean recovery in the irradiated samples was 103.9%.
No degradation products were found above 5% of the total peak area in either the dark, or irradiated samples.
Applicant's summary and conclusion
- Conclusions:
- The test substance is photolytically stable in sterile pH 7 buffer when exposed to continuous artificial light. There were no significant degradation products (i.e., >5% of the total applied radioactivity) determined in the dark or irradiated samples in the study.
- Executive summary:
The rate and nature of degradation of radiolabelled test substance after exposure to simulated sunlight for up to 21 days were determined in sterile pH 7 buffer. This was equivalent to ca 30 days of mid-summer sunlight at latitude of N 40°, assuming a 12 h light/12 h dark cycle. The test was conducted at a nominal concentration of 0.28 µg/mL and samples were exposed to continuous irradiation using a xenon arc lamp until removal for analysis at the appropriate time points (after 0, 1, 2, 3, 6, 8, 10, 13, 16, and 21 days). The study was conducted in compliance with OECD Guideline 316 and US EPA OPPTS 835.2240.
Test vessels were prepared for triazine and phenyl labelled test substance. Half of the test vessels containing test material at the fortification level were subjected to light irradiation at each of the 10 sampling periods, including the zero time analysis. The other half of the test vessels were maintained in the dark. Irradiated and non-irradiated (dark control) test vessels were sampled in duplicate (one for each label) after 0, 1, 2, 3, 6, 8, 10, 13, 16, and 21 days and assayed by LSC for radioactivity. Then, each sample was analyzed with comparisons to radiolabelled standards by HPLC–RAM Detector analysis to validate the identity of the test substance chromatographic peak and certain degradates.
The recovery of radioactivity was calculated based on the percentage of the application rate. The mean recoveries of the dark control samples over 9 post 0-time sampling intervals ranged from 99.3% to 101.0% AR. The overall mean recovery in the dark samples was 99.9% AR. The mean recovery of radioactivity of the irradiated samples over 9 post 0-time sampling intervals ranged from 100.4% to 110.4% AR. The overall mean recovery in the irradiated samples was 103.9%.
The concentrations of the test substance in the pH 7 buffer showed no significant decrease in dark or irradiated samples based on percent of total radioactivity during the course of the study. The percentage of the parent compound was above 95% AR in the dark samples during the course of the study. The same results were also obtained in the irradiated samples. The percentage of the parent compound was also above 95% in the irradiated samples, excepting the results of day 13, where the percentage of the parent compound was approximately 90% AR. No degradation products were found above 5% of the total peak area in either the dark, or irradiated samples.
This study demonstrated that the test substance is photolytically stable in sterile pH 7 buffer when exposed to continuous artificial light. There were no significant degradation products (i.e., >5% of the total applied radioactivity) determined in the dark or irradiated samples in the study.
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