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Diss Factsheets
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EC number: 917-830-2 | CAS number: 1186514-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Guideline method conducted in a reliable laboratory within the spirit of GLP, but without CLP certification.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 19 - <= 252.2 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- > 6.1 - <= 6.6
- Remarks on result:
- other: dependent on loading rate
- Details on results:
- By day 3, the plateau was considered as reached. The measured value of the blank solution lay below the LOQ of TC (< 1.89 mg/L). Dependency of solubility on amount of the test item (nominal load) was perceived in the main study. As solubility was dependent on nominal concentration, no exact value for the solubility of the test item in water can be stated. The solubility range for the tested nominal concentration from 1006 to 10006 mg/L is 19.0 – 252.2 mg/L at 20.0 ± 0.5 °C, corresponding to 1.9 – 3.6 % of the test item relating to the nominal concentration of the test item.
- Conclusions:
- The water solubility of the test substance was dependent on the amount of the test item added. The exact value for the solubility of the test item in water cannot be determined, but is between 19.0 – 252.2 mg/L at 20°C.
Reference
Measurements used in the Calculation of Solubility
Flask |
Measured Conc. Test Item [mg/L] |
Nominal Conc. Test Item [mg/L] |
Dissolved Part [%] |
pH value |
2 |
19.0 |
1006 |
1.89 |
6.12 |
3 |
108.1 |
3004 |
3.60 |
6.48 |
4 |
171.6 |
6010 |
2.86 |
6.34 |
5 |
181.0 |
8004 |
2.26 |
6.54 |
6 |
252.2 |
10006 |
2.52 |
6.45 |
In a graph of the Conc. Test Item (nominal in mg/l) vs Conc. Test Item (measured in mg/l), the following equation was obtained: y = 0.0234x + 15.225. R2 = 0.9473.
Description of key information
19.0 - 252.2 mg/L
Key value for chemical safety assessment
- Water solubility:
- 19 mg/L
- at the temperature of:
- 20 °C
Additional information
The experimental value (Affolter, 2015) of 19.0 mg/ml is used to satisfy the solubility endpoint. Water solubility was found to be dependent upon loading rates. The lower range of the observed values is consistent with ecotoxicity tests which were conducted as a water-accommodated fraction, where the dissolved organic carbon (DOC) analysis did not indicate a significant increase in the DOC measured in the treatment groups (i.e., test loading rates of 1 mg/L, 3.2 mg/L, 10 mg/L, 32 mg/L and/or 100 mg/L) when compared to the blank controls (i.e., 0 mg/L test substance concentration). This indicates an observed solubility well below both experimental values of 252.2 mg/L and 19.0 mg/L in Affolter, 2015, and perhaps even below 3.2 mg/L or 1 mg/L. Note that the water solubility is evaluated in deionized water, whereas the media for aquatic testing contain other salts and constituents, which may explain the inconsistency in solubility values The EPI-Suite water solubility predictions of the principal component were 3.099e-05 mg/L and 8.1322e-07 mg/L, based on two separate estimation models; both estimated values support a conclusion of low water solubility.
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