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Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 December 2015 to 22 March 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP, HPLC method is less suitable for the surface active substance
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: cyanopropyl stationary phase
- Radiolabelling:
- no
- Test temperature:
- 30°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Alliance Separation Module 2695 (Waters, Milford, MA, USA)
- Detector: Refractive index detector 2414 (Waters)
- Column: Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, Waltham, MA, USA)
- Column temperature: 35°C ± 1°C
- Mobile phase: 40/60 (v/v) methanol/water
- Flow: 1 mL/min
- Injection volume: 10 µL
- RI detection
Sensitivity 4
Time constant 1 second
Temperature 30°C
- pH: 7
- Solutes for dissolving test and reference substances: methanol/water 40/60
DETERMINATION OF DEAD TIME: no data
REFERENCE SUBSTANCE: Acetanilide
REPETITIONS: 2 for tes substance, reference substance and blanks
EVALUATION: comparison with retention time referebce substance - Key result
- Type:
- Koc
- Value:
- < 18
- Temp.:
- 30 °C
- Key result
- Type:
- log Koc
- Value:
- < 1.26
- Temp.:
- 30 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 2.415 and 2.420 min
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The logKoc of the substance is <1.26
- Executive summary:
Using the HPLC method the logKoc of the substance was determined to be <1.26.
Reference
Kocof the test item
Substance |
tr,1 |
tr,2 |
mean tr |
log Koc |
Koc |
Acetanilide |
2.415 |
2.420 |
|
1.26 |
|
Test item |
1.475 |
1.474 |
1.475 |
< 1.26 |
<18 |
Description of key information
Using the HPLC method the logKoc of the substance was determined to be <1.26.
Key value for chemical safety assessment
- Koc at 20 °C:
- 18
Additional information
The log Koc calculation in the BASF study is not further taken into account, as a study on the actual test substance is available.
[LogKoc: 1.26]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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