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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Jul - 16 Aug 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- adopted in 2008
- Deviations:
- yes
- Remarks:
- Standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted in 1995
- Deviations:
- yes
- Remarks:
- Standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Department of Health, London, UK
- Type of method:
- flask method
Test material
Constituent 1
- Specific details on test material used for the study:
- Storage conditions: room temperature in the dark
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 667.53 - <= 814.97 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 9.4 - <= 10
- Remarks on result:
- other:
- Remarks:
- Water solubility determined based on visual inspection
- Details on results:
- The standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced. It was therefore not possible to prepare samples at five times the saturation level as recommended in the guidelines. No analysis could be performed due to the high solubility producing unfilterable mixtures.
Therefore the water solubility was determined based on visual inspection.
Any other information on results incl. tables
Preliminary test
Results of the preliminary estimate of water solubility are shown in the following table.
Table 3
Concentration [% w/w] |
Observation |
pH |
10.0 |
Dark yellow/brown solution with no excess test item present |
8.6 |
30.0 |
Dark yellow/brown solution with no excess test item present |
9.6 |
50.0 |
Dark yellow/brown solution with excess test item present |
9.6 |
74.9 |
Yellow/brown wet looking solid |
- |
80.0 |
Yellow/brown solid, no liquid present |
- |
90.0 |
Yellow/brown solid, no liquid present |
- |
Preliminary test result: water solubility in the range 30.0 to 50.0% w/w at 20.0 ± 0.5 °C.
Definitive test
The results of the definitive test for the water solubility are shown in the following table.
Table 4
Concentration [% w/w] |
Observation |
pH |
35.1 |
Dark yellow/brown solution, no excess test item visible |
9.1 |
40.0 |
Dark yellow/brown solution, no excess test item visible |
9.4 |
44.9 |
Dark yellow/brown solution, with small amount of undissolved test item floating within the solution |
10.0 |
Water solubility in the range 40.0 to 44.9% w/w at 20.0 ± 0.5 °C. This corresponds to 667,53 to 814,97 g/L.
Discussion
The standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced. It was therefore not possible to prepare samples at five times the saturation level as recommended in the guidelines. No analysis could be performed due to the high solubility producing unfilterable mixtures.
Therefore the water solubility was determined based on visual inspection.
Conclusion
The water solubility of the test item has been determined to be in the range of 40.0 to 44.9% w/w of solution at 20.0 ± 0.5 °C.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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