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EC number: 630-324-3 | CAS number: 861229-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1999-08-04 to 2000-01-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- MCPP-P DMA
Batch No.: 9158/7(91-1)
Purity: 76.6 % - Analytical monitoring:
- yes
- Details on sampling:
- Sampling at 0 and 72 h. 15 - 20 mL aliquotes were collected from each prepared concentration.
- Vehicle:
- no
- Details on test solutions:
- The test substance was MCPP-P DMA. Based on a range finding test the definitive concentrations were set to 0, 5.6, 14.3, 35.8, 90, 224 mg/L nominal as MCPP-P acid. The test concentrations were measured at the beginning and the end of test exposure period as MCPP-P acid.
- Test organisms (species):
- Anabaena flos-aquae
- Details on test organisms:
- Anabaena flos-aquae (strain CCAP 1403/13B)
Source: Culture collection of Algae and Protozoa (CCAP), Ambleside, Cumbria, UK - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- no data
- Test temperature:
- 23.4 - 25.2 °C
- pH:
- 6.8 - 7.3
- Dissolved oxygen:
- no data
- Salinity:
- NA
- Conductivity:
- no data
- Nominal and measured concentrations:
- Equivalent to MCPP-P acid concentrations:
nominal: 0, 5.6, 14.3, 35.8, 90, 224 mg/L
measured: 0, 5.955, 14.3, 36.17, 91.35, 227.4 mg/L - Details on test conditions:
- The test flasks were 250 mL Erlenmeyer flasks capped with foil lids. Three replicates and six controls were used. The medium was prepared according to guideline. Illumunation was provided by artifical fluorescent tubes at light intensity of 7610 lux. The alga growth inhibition was measured by cell counting after 24, 48 and 72 hours under microscope and Sedgewick-Rafter or Neubauer Counting Chambers depending on cell numbers present.
- Reference substance (positive control):
- no
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 28.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P DMA
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 23.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P acid
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P DMA
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.956 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P acid
- Reported statistics and error estimates:
- The EC50-value and NOEC were calculated by probit transformation and regression analysis. According to OECD the 100 % inhibition observed in the highest exposure groups were not included in the EC50 estimation. The Pearson chi-squared goodness of fit test statistic was statistically significant at the 1 % level for AUG (0 - 72 h) and the growth inhibition curve for each of the concentration curves. As a result, the EC50 value reported can only be used as indicative of the EC50 as the probit fit to the data was not good, i.e. the data were not adequately spread over 0 % to 100%.
- Validity criteria fulfilled:
- yes
- Conclusions:
- For MCPP-P acid, the hydrolysis product of MCPP-P 2-EHE, a 72h-EC50 of 23.9 mg/L and a 72h-NOEC of 5.96 mg/L were determined on the alga Anabaena flos-aquae.
- Executive summary:
The effect of MCPP-P DMA salf upon the growth of Anabaena flos-aquae a freshwater blue-green alga, was determined over a 72 h period, in a test based on procedures in OECD 201 (1984).
The nominal concentrations of MCPP-P DMA salt whole product tested were 268, 107, 43, 17, 6.7 and 0 mg/L corresponding to 224, 90, 36, 14, 5.6 and 0 mg/L MCPP-P acid, respectively.The measured concentration were 227.4, 91.35, 36.17, 14.30, 5.956 and 0 mg/L as MCPP-P acid. The EC50 and the NOEC were calculated and reported for both MCPP-P DMA and the MCPP-P acid.
The EC50 for the salt was determened to be 28.9 mg/L, where for the acid it was 23.9 mg/L. The NOEC based on the MCPP-P DMA salt was 7.21 mg/L and based on the MCPP-P acid was 5.956 mg/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to section 13 for "Read Across justification".
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 28.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P DMA
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 23.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P acid
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P DMA
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.956 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: MCPP-P acid
Referenceopen allclose all
Description of key information
For MCPP-P acid, the hydrolysis product of MCPP-P 2-EHE, a 72h-EC50 of 23.9 mg/L and a 72h-NOEC of 5.956 mg/L were determined on the alga Anabaena flos-aquae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 23.9 mg/L
- EC10 or NOEC for freshwater algae:
- 5.956 mg/L
Additional information
The toxicity to aquatic algae and cyanobacteria was investigated with MCPP-P acid (read-across).
The effect of MCPP-P DMA salf upon the growth of Anabaena flos-aquae a freshwater blue-green alga, was determined over a 72 h period, in a test based on procedures in OECD 201 (1984).
The nominal concentrations of MCPP-P DMA salt whole product tested were 268, 107, 43, 17, 6.7 and 0 mg/L corresponding to 224, 90, 36, 14, 5.6 and 0 mg/L MCPP-P acid, respectively. The measured concentration were 227.4, 91.35, 36.17, 14.30, 5.956 and 0 mg/L as MCPP-P acid. The EC50 and the NOEC were calculated and reported for both MCPP-P DMA and the MCPP-P acid.
The EC50 for the salt was determined to be 28.9 mg/L, where for the acid it was 23.9 mg/L. The NOEC based on the MCPP-P DMA salt was 7.21 mg/L and based on the MCPP-P acid was 5.956 mg/L.
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