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EC number: 280-349-5 | CAS number: 83261-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- day of application: between 1983-10-14 and 1983-11-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (non-GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- BASF-Test, principally according to OECD guideline 401.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 83216-15-8
- IUPAC Name:
- 83216-15-8
- Details on test material:
- - Name of test material (as cited in study report): L-chloropropionic acid isobutyl ester
No further data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male and female Wistar rats
- Source: Dr. K. Thomae, Biberach, Germany
- Age at study initiation: no data
- Weight at study initiation: group mean body weights: 196-199 g (males), 181-188 g (females)
- Fasting period before study: yes. Food was withdrawn 16 h prior to dosing but the animals still received water ad libitum
- Housing: 5 per cage, steel wire mesh cages, type DK III (Becker)
- Diet (ad libitum): Kliba laboratory diet, Klingentalmühle, Kaiseraugst, Switzerland
- Water (ad libitum): tap water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
0.5% aqueous carboxymethylcellulose
- Concentration in vehicle: 5.62 - 26.10% (w/v)
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw - Doses:
- 562, 1000, 1780, 2610 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology - Statistics:
- LD50 was calculated by Probit analysis (Finney DJ (1971). Probit Analysis, Cambridge University Press, 3rd. ed.).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 490 mg/kg bw
- 95% CL:
- 1 150 - 1 880
- Remarks on result:
- other: slope factor: 1.50
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 650 mg/kg bw
- 95% CL:
- 970 - 3 990
- Remarks on result:
- other: slope factor: 1.85
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 1 780 mg/kg bw
- Remarks on result:
- other: 5% significance level
- Mortality:
- Totally, 1/10, 9/10, and 8/10 rats given 1000, 1780, and 2610 mg/kg bw, respectively, died. All deaths have to be considered as late deaths. For details, see table below.
- Clinical signs:
- other: Clinical signs of toxicity were observed in rats treated with 1780 and 2610 mg/kg bw. In males treated with 2610 and 1780 mg/kg bw, dyspnea, apathy, staggering, atony, paresis, twitching, piloerection, imbalance, and poor general state were observed. Sym
- Gross pathology:
- In decedents (males and females), general congestive hyperemia and occasionally contentless stomach and gut was observed. No pathological findings were noted in survivors that had been sacrificed at the end of the observation period.
Any other information on results incl. tables
Table 1: mortality rates
a) males
Dose [mg/kg] |
2610 |
1780 |
1000 |
562 |
No. of rats |
5 |
5 |
5 |
5 |
Dead animals after |
||||
1 h |
0 |
0 |
0 |
0 |
1 d |
0 |
0 |
0 |
0 |
2 d |
0 |
0 |
0 |
0 |
7 d |
3 |
4 |
1 |
0 |
14 d |
3 |
4 |
1 |
0 |
b) females
Dose [mg/kg] |
2610 |
1780 |
1000 |
562 |
No. of rats |
5 |
5 |
5 |
5 |
Dead animals after |
||||
1 h |
0 |
0 |
0 |
0 |
1 d |
0 |
0 |
0 |
0 |
2 d |
0 |
0 |
0 |
0 |
7 d |
5 |
5 |
0 |
0 |
14 d |
5 |
5 |
0 |
0 |
Table 2: group mean body weights [g]
a) males
dose[mg/kg] |
2610 |
1870 |
100 |
562 |
start of the study |
196 |
198 |
198 |
199 |
after 3 d |
164 |
164 |
201 |
240 |
after 7 d |
160 |
180 |
236 |
258 |
after 13 d |
213 |
220 |
266 |
285 |
b) females
dose[mg/kg] |
2610 |
1870 |
100 |
562 |
start of the study |
181 |
188 |
187 |
187 |
after 3 d |
160 |
151 |
190 |
217 |
after 7 d |
- |
- |
211 |
223 |
after 13 d |
- |
- |
223 |
235 |
Applicant's summary and conclusion
- Executive summary:
The test substance was suspended in 0.5% aqueous CMC and administered by gavage to groups of 5 male and 5 female Wistar rats. The animals received doses of 562, 1000, 1780, and 2610 mg/kg bw and were observed for 14 days.
Mortality was 1/10, 9/10, and 8/10 in the groups given 1000, 1780, and 2610 mg/kg bw, respectively. All deaths were late deaths. Clinical signs of toxicity were noted at 1780 and 2610 mg/kg bw and comprised dyspnea, apathy, staggering, atony, paresis, twitching, piloerection, imbalance, and poor general state were observed. Symptoms were observed first at 3 days post dose and partially persisted until day 13 post dose. Animals of the two highest dose groups initially lost weight; but survivors recovered within the observation period. Pathological examination revealed general congestive hyperemia and occasionally contentless stomach and gut in decedents whereas no pathological findings were noted in survivors.
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