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EC number: 207-256-4
CAS number: 456-04-2
1. Main experiment:
The influence of
routes of induction and challenge on elicitation response in guinea pigs
sensitized to alpha-chloroacetophenone:
No. of positive animals / no. of total animals
The results were from
skin reactions read at 48 hrs after the first challenge.
The effect of route
and dosage of substance administration on the sensitization of guinea
pigs to alpha-chloroacetophenone:
i.d. & top.
FR: Fraction of
positive responses or fractional response.
Net FR: The difference
between the FRs of sensitized and unimmunized controls.
AI: Average intensity
of the numerical scores of skin reactions.
Net AI: The difference
between the AI values of immunized and untreated controls.
AATI: Average of area
times reaction intensity of positive skin reactions.
AATI ratio: The ratio
of AATI of immunized to that of untreated control animals.
The number of animals
in each immunization dose group was six or eight and all animals
received either an i.d.or a topical challenge in the first challenge. In
the second challenge they were divided into two groups. One group was
challenged by the i.d route with 1.0 µg CN/site, the lowest dose in the
first challenge, and the other received the topical challenge.
The blank spaces
indicate that the animals were not tested.
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