Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-256-4 | CAS number: 456-04-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment. Report on a case of human allergic contact dermatitis induced by the test substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from 3-(α-methoxy)methylenebenzofuran-2(3H)-one (MBF) and α-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.
- Author:
- Boffa MJ, Heron RJL, Wilkinson SM, Beck MH
- Year:
- 1 996
- Bibliographic source:
- Contact Dermatitis 34: 434-435
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Case report on occupational sensitization to the test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- α-chloro-4-fluoroacetophenone
- EC Number:
- 207-256-4
- EC Name:
- α-chloro-4-fluoroacetophenone
- Cas Number:
- 456-04-2
- Molecular formula:
- C8H6ClFO
- IUPAC Name:
- 2-chloro-1-(4-fluorophenyl)ethan-1-one
- Details on test material:
- - Name of test material (as cited in study report): α-chloro-4-fluoroacetophenone (CFAP)
- Substance type: organic chemical intermediate
- Physical state: not reported
- Analytical purity: not reported
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 44
- Race: no data - Clinical history:
- - History of allergy or casuistics for study subject or populations: no data
- Symptoms, onset and progress of the disease: 18-month history of recurrent facial eczema.
- Exposure history: regular occupational handling of the test substance
- Aggravating factors both in home and workplace: no data
- Family history: not applicable - Controls:
- not applicable
- Route of administration:
- other: dermal and inhalation possible
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: not reported
- Vehicle / solvent: toluene
- Concentrations: 0.005%
- Volume applied: not reported
- Testing/scoring schedule: readings after 2 and 4 days
- Removal of test substance: no data
EXAMINATIONS
- Grading/Scoring system: not reported
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: skin problems of patient developed only at work
RESULT OF CASE REPORT: Patient appeared to have been sensitized following occupational exposure
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
