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Diss Factsheets
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EC number: 261-629-6 | CAS number: 59151-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- The study was performed on a similar substance to the registered substance and as such is considered to be sufficient to address the endpoint by read-across.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 0.5 ml (or 0.2g) of the test material is applied to a semi-occlusive patch which is then placed on the clipped dorsum of rabbits. The patch remains on the animal for four hours. Irritation reactions are assessed immediately after removal of the patch and thereafter at 24, 48 and 72 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl 3-oxo-2-pentylcyclopentaneacetate
- EC Number:
- 246-495-9
- EC Name:
- Methyl 3-oxo-2-pentylcyclopentaneacetate
- Cas Number:
- 24851-98-7
- Molecular formula:
- C13H22O3
- IUPAC Name:
- Methyl 3-oxo-2-pentyl-1-cyclopentaneacetate
Constituent 1
- Specific details on test material used for the study:
- Test material name (as stated in the report) : Methyl Dihydrojasmonate (S15102-T01)
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals bought from a commercial supplier are used for testing the hair is in a non-growth (telogen) phase of the hair cycle.
Three to four days prior to the testing the backs and flanks of 9 to 12 week old rabbits are cliipped to identify those which are in telogen and which have no skin blemishes. Of these rabbits, 8 are selected for the test. The hair is given a final clip approximately 2 hours prior the treatment. Throughout the test the rabbit are housed individually in suspended cages with wire mesh floor. They have free access to tap water and pelleted rabbit diet with vitamin and mineral supplements.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of test substance (100% concentration) is applied
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48 and 72 hours after treatment
- Number of animals:
- 8 rabbits
- Details on study design:
- The test material is applied to every rabbit in this test: up to 6 patches can be applied to each rabbit. Prior to treatment a plan (based on random number sequence) is prepared on application sites of each substance on each rabbit. When all patches have been applied to a rabbit it is immobilized in a canvas body sleeve and placed in a quiet place for the 4 hour application period, at the end, of which the animals are removed from the body sleeves and the corners of each treatment site marketed. The patches are then removed and excess substance wiped from the skin with damp tissue.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1331; 1352 and 1410
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 72 hours
- Remarks:
- hours
- Irritation parameter:
- erythema score
- Basis:
- animal: 1412
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72
- Remarks:
- hours
- Irritation parameter:
- erythema score
- Basis:
- animal: 1415;1419 and 1420
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72
- Remarks:
- hours
- Irritation parameter:
- erythema score
- Basis:
- animal: 1416
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72
- Remarks:
- hours
- Irritation parameter:
- edema score
- Basis:
- animal: 1412
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 72
- Remarks:
- hours
- Irritation parameter:
- edema score
- Basis:
- animal: 1331; 1352; 1410 and 1419
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 1
- Reversibility:
- other: fully reversible within 72 hours: 1352 and 1419
- Remarks on result:
- other: Not fully reversible within 72 hours: 1331; 1410
- Irritation parameter:
- edema score
- Basis:
- animal: 1416
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72
- Remarks:
- hours
- Irritation parameter:
- edema score
- Basis:
- animal: 1415 and 1420
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72
- Remarks:
- hours
- Irritant / corrosive response data:
- Immediately after removal of the patches, all eight animals showed slight erythema and/or slight oedema. 72 hours after patch removal these effects had reduced in nine animals to show very slight erythema and/or slight oedema in four animals with three animals entirely normal. The remaining animals showed slight/moderate erythema/oedema at 72 hours.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this test, Methyl Dihydrojasmonate (S15102-T01) showed slight irritancy, nevertheless the effects observed do not met the criteria for skin irritation classication according the CLP Regulation (EC) No. 1272/2008.
- Executive summary:
Methyl Dihydrojasmonate is tested to demonstrate the skin irritation potential. 0.5 ml (or 0.2g) of the test material is applied to a semi-occlusive patch which is then placed on the clipped dorsum of rabbits. The patch remains on the animal for four hours. Irritation reactions are assessed immediately after removal of the patch and thereafter at 24, 48 and 72 hours. Immediately after removal of the patches, all eight animals showed slight erythema and/or slight oedema. 72 hours after patch removal these effects had reduced in four animals to show very slight erythema and/or slight oedema with three animals entirely normal. The remaining animals showed slight/moderate erythema/oedema at 72 hours.
Therefore it can be concluded that under the conditions of this test, Methyl Dihydrojasmonate (S15102-T01) showed slight irritancy, nevertheless the effects observed do not met the criteria for classication according the CLP Regulation (EC) No. 1272/2008.
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