Registration Dossier
Registration Dossier
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EC number: 210-789-5 | CAS number: 623-36-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1950 - 54
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline study. No GLP.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 954
- Reference Type:
- review article or handbook
- Title:
- no data
- Author:
- N.N.
- Year:
- 2 011
- Bibliographic source:
- Registry of Toxic effects Of Chemical Substances (RTECS) - "Prehled Prumyslove Toxikologie: Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,273,1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute skin irritation/corrosion.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylpent-2-enal
- EC Number:
- 210-789-5
- EC Name:
- 2-methylpent-2-enal
- Cas Number:
- 623-36-9
- Molecular formula:
- C6H10O
- IUPAC Name:
- 2-methylpent-2-enal
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- no data
- Number of animals:
- 5 animals (sex not specified)
- Details on study design:
- Primary skin irritation on rabhits records in a 10-grade ordinal series the severest reaction on the clipped skin of any of five albino rabbits within 24 hours of application of 0.01 ml. of undiluted sample.
Grade 1 indicates the least visible capillary Injection from undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01 % solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- no data
- Irritant / corrosive response data:
- 2-Methyl-2-pentene-1-al caused mild irritation when applied to the rabbit skin (Grade 2 on a scale of 10).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
