Registration Dossier
Registration Dossier
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EC number: 205-257-4 | CAS number: 136-77-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974., p. 548
- Author:
- Grant, W. M.
- Year:
- 1 974
- Bibliographic source:
- Toxnet
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no guideline provided
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-hexylresorcinol
- EC Number:
- 205-257-4
- EC Name:
- 4-hexylresorcinol
- Cas Number:
- 136-77-6
- Molecular formula:
- C12H18O2
- IUPAC Name:
- 4-hexylresorcinol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- 1:10000, 1:1000
- Duration of treatment / exposure:
- 5 min
Results and discussion
In vitro
Results
- Irritation parameter:
- other: no score recorded
- Remarks on result:
- positive indication of irritation
- Other effects / acceptance of results:
- Tests on rabbit eyes have shown that surface of cornea can be irrigated for 5 min with 1:10,000 solution without injury, but that irrigationwith 1:1,000 solution for 1-5 min caused diffuse edema of epithelium, followed in 2 or 3 hr by bluish stromal edema and hyperemia of iris.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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