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EC number: 203-116-1 | CAS number: 103-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: The oral LD50 value for the test substance was found to be 5000 mg/kg bw.
Dermal: The dermal LD50 value for the test substance was found to be greater than 5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 1 week - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: mortalities were recorded daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- The number of deaths were used to calculate the LD50 value.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 3 males died on day 1,
1 female died on day 2. - Clinical signs:
- other: Diuresis, crawling on stomach, slowed coordination, pilo erection, prostration, coma and death were observed. The surviving animals showed signs of recovery on the 3rd day.
- Gross pathology:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study the LD50 value was determined to be >5000 mg/kg bw.
- Executive summary:
An acute oral toxicity study was conducted on 10 rats (5 male and 5 female animals). The test material was applied in one (limit) concentration of 5000 mg/kg bw by gavage. The animals were observed for a period of 14 days. Symptoms that were observed during this period were diuresis soon after dosing, crawling, slowed coordination, pilo erection, morbidity, prostration, coma and death. 3 males died on day 1, one female died on day 2. The surviving animals showed signs of recovery on the third day of observation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Summary of study results, basic information given, sufficient for assessment.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Method described under Section 191.10 of the Final Order, Enforcement Regulations, Federal Register, Vol 26, No 155, p 7336, 12 August 1961.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST MATERIAL
- Amount applied: 5 g/kg bw - Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- 3 animals with intact skin and 3 animals with abraded skin were tested.
- Control animals:
- not required
- Statistics:
- The LD50 was calculated based on the test results.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 animals of the intact skin group and 1 animal of the abraded skin group died on day 1.
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was found to be greater than 5000 mg/kg bw.
- Executive summary:
An acute dermal toxicity study was conducted on 6 rabbits. The test material was applied in one (limit) concentration of 5000 mg/kg bw to the intact skin of 3 of the test animals, test sites on the other animals were abraded before application. As a result, 2 rabbits died (one of the intact-skin test group and one of the abraded-skin test group). Morbidity, prostration and coma were observed before death. Based on the available data, the LD50 was determined to be greater than 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Summary of study results, basic information given, sufficient for assessment
Additional information
Oral
An acute oral toxicity study was conducted on 10 rats (5 male and 5 female animals). The test material was applied in one (limit) concentration of 5000 mg/kg bw by gavage. The animals were observed for a period of 14 days. Symptoms that were observed during this period were diuresis soon after dosing, crawling, slowed coordination, pilo erection, morbidity, prostration, coma and death. 3 males died on day 1, one female died on day 2. The surviving animals showed signs of recovery on the third day of observation.
Dermal
An acute dermal toxicity study was conducted on 6 rabbits. The test material was applied in one (limit) concentration of 5000 mg/kg bw to the intact skin of 3 of the test animals, test sites on the other animals were abraded before application. As a result, 2 rabbits died (one of the intact-skin test group and one of the abraded-skin test group). Morbidity, prostration and coma were observed before death. Based on the available data, the LD50 was determined to be greater than 5000 mg/kg bw.
Justification for classification or non-classification
Classification,
Labelling, and Packaging Regulation (EC) No 1272/2008
The
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. Based on
available data on acute toxicity, the
test item is not classified according
to Regulation (EC) No 1272/2008 (CLP), as amended for the eighth time in
Regulation (EU) No 2016/918.
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