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EC number: 257-269-4 | CAS number: 51548-48-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from predicted model QSAR Toolbox version 3.3
- Justification for type of information:
- Data is from predicted model QSAR Toolbox version 3.3
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction is done using QSAR Toolbox version 3.3
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): (5or8)-aminonaphthalene-2-sulphonic acid
- Molecular formula (if other than submission substance): C10-H9-N-O3-S
- Molecular weight (if other than submission substance): 223.2511
- Smiles notation (if other than submission substance): c1cc2cc(ccc2c(c1)N)S(=O)(=O)O
- InChl (if other than submission substance): 1S/C10H9NO3S/c11-10-3-1-2-7-6-8(15(12,13)14)4-5-9(7)10/h1-6H,11H2,(H,12,13,14)
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Details on sampling:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- not specified
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Hardness:
- No data
- Test temperature:
- 20 deg.C
- pH:
- 6.7-7.8
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 176.189 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a" or "b" or "c" or "d" or "e") and "f") and("g" and "h") )
Domain logical expression index: "a"
Referential boundary:The target chemical should be classified as Anilines (Acute toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary:The target chemical should be classified as Aniline AND Aryl AND Fused carbocyclic aromatic AND Naphtalene AND Sulfonic acid by Organic Functional groups
Domain logical expression index: "c"
Referential boundary:The target chemical should be classified as Aniline AND Fused carbocyclic aromatic AND Naphtalene AND Overlapping groups AND Sulfonic acid by Organic Functional groups (nested)
Domain logical expression index: "d"
Referential boundary:The target chemical should be classified as Aliphatic Nitrogen, one aromatic attach [-N] AND Aromatic Carbon [C] AND Hydroxy, sulfur attach [-OH] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] AND Suflur {v+4} or {v+6} AND Sulfinic acid [-S(=O)OH] AND Sulfonate, aromatic attach [-SO2-O] by Organic functional groups (US EPA)
Domain logical expression index: "e"
Referential boundary:The target chemical should be classified as Amine AND Aromatic compound AND Primary amine AND Primary aromatic amine AND Sulfonic acid AND Sulfonic acid derivative by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "f"
Referential boundary:The target chemical should be classified as Class 5 (Not possible to classify according to these rules) by Acute aquatic toxicity classification by Verhaar (Modified) ONLY
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.92
Domain logical expression index: "h"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.24
- Validity criteria fulfilled:
- not specified
- Conclusions:
- By QSAR Toolbox version 3.3 predicted model the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish was estimated to be 176.189147949 mg/l for 96 hrs in static condition for test substance (5or8)-aminonaphthalene-2-sulphonic acid with mortality effects.
- Executive summary:
By QSAR Toolbox version 3.3 predicted model the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish was estimated to be 176.189147949 mg/l for 96 hrs in static condition for test substance (5or8)-aminonaphthalene-2-sulphonic acid with mortality effects.
Thus based on predicted value concluded that the test substance (5or8)-aminonaphthalene-2-sulphonic acid is non toxic to fish.
Reference
Description of key information
By QSAR Toolbox version 3.3 predicted model the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish was estimated to be 176.189147949 mg/l for 96 hrs in static condition for test substance (5or8)-aminonaphthalene-2-sulphonic acid with mortality effects.
Thus based on predicted value concluded that the test substance (5or8)-aminonaphthalene-2-sulphonic acid is non toxic to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 176.189 mg/L
Additional information
Short term toxicity to fish was assessed for the target compound (5or8)-aminonaphthalene-2-sulphonic acid (CAS no 51548-48-2) and its related read- across by reviewing a number of studies. The summary of the results are presented below:
Short term aquatic toxic effects of the test compound (5or8)-aminonaphthalene-2-sulphonic acid (CAS no 51548-48-2) was predicted (SSS QSAR, 2016). The study was based on the effects of the test compound on the fish species Brachydanio rerio (new name: Danio rerio) in 96 hrs duration in a fresh water static system. The predicted data suggests the lethal concentration (LC50) for (5or8)-aminonaphthalene-2-sulphonic acid on the basis of mortality to be 176.1891 mg/L. This value concluded that the test compound (5or8)-aminonaphthalene-2-sulphonic acid does not exhibit short term toxicity to fish (Brachydanio rerio (new name: Danio rerio)) and is non hazardous to the aquatic environment.
Other predicted model ECOSAR Version 1.10 indicate that, the 96 hours LC50 was estimated to be 74690.617mg/l on fish for substance (5or8)-aminonaphthalene-2-sulphonic acid with mortality effects.
Whereas experimental study (Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994) for read across substance 6-aminonaphthalene-1,3-disulphonic acid (118-33-2)indicate that the lethal concentration (LC0) of test substance for fish Leuciscus idus, Bruchydunio rerio,Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate was found to be 1000 mg/l for 96 hrs.
And other database (Data bank of Environmental Properties of Chemicals (EnviChem), 2014) for read across Sodium naphthionate (Cas no.130-13-2)indicate that the median lethal concentration (LC50) of test substance substance Sodium naphthionate for fish Oryzias latipes was found to be >4000 mg/l for 48 hrs. on the basis of mortality effects.
Based on above available studies it is concluded that the substance (5or8)-aminonaphthalene-2-sulphonic acid (CAS no 51548-48-2) not qualify for the aquatic classification as per the CLP criteria.
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