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EC number: 209-886-5 | CAS number: 596-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
The skin irritation potential for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated using OECD QSAR toolbox version 3.4 The test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated to be not irritating to skin of New Zealand White rabbits.
Eye Irritation:
The ocular irritation potential of Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated using OECD QSAR toolbox v3.4
Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction is done using QSAR Toolbox version 3.4
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.4
- GLP compliance:
- no
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl -
-Molecular formula: C31H43N3O1
Molecular weight: 473.71g/mol
Smiles notation: OC(c(ccc(N(CC)CC)c1)c1)(c(ccc(N(CC)CC)c2)c2)c(ccc(N(CC)CC)c3)c3
Substance type: Organic
Physical State: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 male rabbits
- Details on study design:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- no data
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no irritation was observed on test rabbits.
- Interpretation of results:
- not irritating
- Conclusions:
- The substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6) is estimated to be not irritating to skin of New Zealand White rabbits.
- Executive summary:
The skin irritation potential for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated using OECD QSAR toolbox version 3.4 The test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated to be not irritating to skin of New Zealand White rabbits.
Reference
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((("a"
or "b" or "c" or "d") and("e"
and(not
"f")) ) and("g"
and(not
"h")) ) and("i"
and(not
"j")) ) and("k"
and(not
"l")) ) and("m"
and "n") )
Domain
logical expression index: "a"
Referential
boundary:The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aliphatic
Nitrogen, one aromatic attach [-N] AND Amino, aliphatic attach [-N<] AND
Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic
functional groups (US EPA)
Domain
logical expression index: "b"
Referential
boundary:The
target chemical should be classified as Amine AND Anion AND Aromatic
compound AND Cation AND Tertiary amine AND Tertiary mixed amine by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "c"
Referential
boundary:The
target chemical should be classified as Alkene AND Ammonium salt AND
Aromatic amine AND Aryl by Organic Functional groups
Domain
logical expression index: "d"
Referential
boundary:The
target chemical should be classified as Alkene AND Ammonium salt AND
Aromatic amine AND Overlapping groups by Organic Functional groups
(nested)
Domain
logical expression index: "e"
Referential
boundary:The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.4
Domain
logical expression index: "f"
Referential
boundary:The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition, quinoid structures OR AN2 >> Michael-type addition, quinoid
structures >> Quinoneimines OR AN2 >> Michael-type addition, quinoid
structures >> Quinones and Trihydroxybenzenes OR AN2 >> Nucleophilic
addition reaction with cycloisomerization OR AN2 >> Nucleophilic
addition reaction with cycloisomerization >> Hydrazine Derivatives OR
AN2 >> Schiff base formation by aldehyde formed after metabolic
activation OR AN2 >> Schiff base formation by aldehyde formed after
metabolic activation >> Geminal Polyhaloalkane Derivatives OR AN2 >>
Shiff base formation after aldehyde release OR AN2 >> Shiff base
formation after aldehyde release >> Specific Acetate Esters OR
Non-covalent interaction OR Non-covalent interaction >> DNA
intercalation OR Non-covalent interaction >> DNA intercalation >> Amino
Anthraquinones OR Non-covalent interaction >> DNA intercalation >> DNA
Intercalators with Carboxamide and Aminoalkylamine Side Chain OR
Non-covalent interaction >> DNA intercalation >> Fused-Ring Primary
Aromatic Amines OR Non-covalent interaction >> DNA intercalation >>
Quinones and Trihydroxybenzenes OR Radical OR Radical >> Generation of
ROS by glutathione depletion (indirect) OR Radical >> Generation of ROS
by glutathione depletion (indirect) >> Haloalkanes Containing Heteroatom
OR Radical >> Radical mechanism via ROS formation (indirect) OR Radical
>> Radical mechanism via ROS formation (indirect) >> Amino
Anthraquinones OR Radical >> Radical mechanism via ROS formation
(indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >> Radical
mechanism via ROS formation (indirect) >> Geminal Polyhaloalkane
Derivatives OR Radical >> Radical mechanism via ROS formation (indirect)
>> Hydrazine Derivatives OR Radical >> Radical mechanism via ROS
formation (indirect) >> Nitroaniline Derivatives OR Radical >> Radical
mechanism via ROS formation (indirect) >> Nitroarenes with Other Active
Groups OR Radical >> Radical mechanism via ROS formation (indirect) >>
Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR Radical >>
Radical mechanism via ROS formation (indirect) >> Quinones and
Trihydroxybenzenes OR Radical >> Radical mechanism via ROS formation
(indirect) >> Single-Ring Substituted Primary Aromatic Amines OR Radical
>> ROS formation after GSH depletion (indirect) OR Radical >> ROS
formation after GSH depletion (indirect) >> Quinoneimines OR SN1 OR SN1
>> Nucleophilic attack after carbenium ion formation OR SN1 >>
Nucleophilic attack after carbenium ion formation >> Specific Acetate
Esters OR SN1 >> Nucleophilic attack after diazonium or carbenium ion
formation OR SN1 >> Nucleophilic attack after diazonium or carbenium ion
formation >> Nitroarenes with Other Active Groups OR SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation >> Amino Anthraquinones
OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >>
Fused-Ring Primary Aromatic Amines OR SN1 >> Nucleophilic attack after
nitrenium ion formation OR SN1 >> Nucleophilic attack after nitrenium
ion formation >> Single-Ring Substituted Primary Aromatic Amines OR SN1
>> Nucleophilic attack after reduction and nitrenium ion formation OR
SN1 >> Nucleophilic attack after reduction and nitrenium ion formation
>> Nitroaniline Derivatives OR SN1 >> Nucleophilic attack after
reduction and nitrenium ion formation >> Nitroarenes with Other Active
Groups OR SN1 >> Nucleophilic attack after reduction and nitrenium ion
formation >> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR
SN2 OR SN2 >> Acylation OR SN2 >> Acylation >> Specific Acetate Esters
OR SN2 >> Acylation involving a leaving group after metabolic activation
OR SN2 >> Acylation involving a leaving group after metabolic activation
>> Geminal Polyhaloalkane Derivatives OR SN2 >> Alkylation, direct
acting epoxides and related after cyclization OR SN2 >> Alkylation,
direct acting epoxides and related after cyclization >> Nitrogen and
Sulfur Mustards OR SN2 >> Alkylation, nucleophilic substitution at
sp3-carbon atom OR SN2 >> Alkylation, nucleophilic substitution at
sp3-carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >> Direct
nucleophilic attack on diazonium cation OR SN2 >> Direct nucleophilic
attack on diazonium cation >> Hydrazine Derivatives OR SN2 >>
Nucleophilic substitution at sp3 Carbon atom OR SN2 >> Nucleophilic
substitution at sp3 Carbon atom >> Haloalkanes Containing Heteroatom OR
SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Specific Acetate
Esters OR SN2 >> Nucleophilic substitution at sp3 carbon atom after
thiol (glutathione) conjugation OR SN2 >> Nucleophilic substitution at
sp3 carbon atom after thiol (glutathione) conjugation >> Geminal
Polyhaloalkane Derivatives OR SN2 >> SN2 attack on activated carbon Csp3
or Csp2 OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 >>
Nitroarenes with Other Active Groups by DNA binding by OASIS v.1.4
Domain
logical expression index: "g"
Referential
boundary:The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "h"
Referential
boundary:The
target chemical should be classified as Non binder, impaired OH or NH2
group OR Non binder, MW>500 OR Non binder, non cyclic structure OR
Strong binder, NH2 group OR Strong binder, OH group OR Weak binder, OH
group by Estrogen Receptor Binding
Domain
logical expression index: "i"
Referential
boundary:The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "j"
Referential
boundary:The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR SN2 OR SN2 >> SN2 reaction at
sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl diazo
by Protein binding by OECD
Domain
logical expression index: "k"
Referential
boundary:The
target chemical should be classified as AN2 AND AN2 >> Michael addition
to the quinoid type structures AND AN2 >> Michael addition to the
quinoid type structures >> N-Subsituted Aromatic Amines by Protein
binding alerts for Chromosomal aberration by OASIS v.1.2
Domain
logical expression index: "l"
Referential
boundary:The
target chemical should be classified as No alert found by Protein
binding alerts for Chromosomal aberration by OASIS v.1.2
Domain
logical expression index: "m"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 3.28
Domain
logical expression index: "n"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 7.21
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction was done using OECD QSAR toolbox v3.4
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.4
- GLP compliance:
- no
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl -
-Molecular formula:C31H43N3O
Molecular weight: 473.71g/mol
Smiles notation: OC(c(ccc(N(CC)CC)c1)c1)(c(ccc(N(CC)CC)c2)c2)c(ccc(N(CC)CC)c3)c3
Substance type: Organic
Physical State: Solid - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 96 Hours
- Duration of post- treatment incubation (in vitro):
- not specified
- Number of animals or in vitro replicates:
- not specified
- Details on study design:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 96 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed
- Interpretation of results:
- other: not irritating
- Conclusions:
- Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.
- Executive summary:
The ocular irritation potential of Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated using OECD QSAR toolbox v3.4
Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.
Reference
Estimation
method: Takes mode value from the 8 nearest neighbours
Domain logical expression:Result: In Domain
(((((("a"
or "b" or "c" or "d") and("e"
and(not
"f")) ) and("g"
and(not
"h")) ) and("i"
and(not
"j")) ) and("k"
and(not
"l")) ) and("m"
and "n") )
Domain
logical expression index: "a"
Referential
boundary:The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aliphatic
Nitrogen, one aromatic attach [-N] AND Amino, aliphatic attach [-N<] AND
Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic
functional groups (US EPA)
Domain
logical expression index: "b"
Referential
boundary:The
target chemical should be classified as Amine AND Anion AND Aromatic
compound AND Cation AND Tertiary amine AND Tertiary mixed amine by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "c"
Referential
boundary:The
target chemical should be classified as Alkene AND Ammonium salt AND
Aromatic amine AND Aryl by Organic Functional groups
Domain
logical expression index: "d"
Referential
boundary:The
target chemical should be classified as Alkene AND Ammonium salt AND
Aromatic amine AND Overlapping groups by Organic Functional groups
(nested)
Domain
logical expression index: "e"
Referential
boundary:The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CN Lipid Solubility < 0.4
g/kg AND Group All Melting Point > 200 C AND Group CN Aqueous Solubility
< 0.1 g/L AND Group CN Melting Point > 180 C AND Group CN Molecular
Weight > 290 g/mol AND Group CN Vapour Pressure < 0.001 Pa by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "f"
Referential
boundary:The
target chemical should be classified as (!Undefined)Group All log Kow <
-3.1 OR (!Undefined)Group All log Kow > 9 OR (!Undefined)Group All
Melting Point > 200 C OR (!Undefined)Group CNHal Lipid Solubility < 4
g/kg OR (!Undefined)Group CNHal Lipid Solubility < 400 g/kg OR
(!Undefined)Group CNS Surface Tension > 62 mN/m OR Exclusion rules not
met OR Group All log Kow < -3.1 OR Group All log Kow > 9 OR Group C
Aqueous Solubility < 0.0001 g/L OR Group C Melting Point > 55 C OR Group
C Molecular Weight > 350 g/mol OR Group C Vapour Pressure < 0.0001 Pa OR
Group CN Aqueous Solubility < 0.0001 g/L OR Group CN log Kow > 4.5 OR
Group CN log Kow > 5.5 OR Group CN Molecular Weight > 540 g/mol OR Group
CNHal Aqueous Solubility < 0.001 g/L OR Group CNHal Aqueous Solubility <
0.1 g/L OR Group CNHal log Kow > 3.8 OR Group CNHal Molecular Weight >
370 g/mol OR Group CNHal Molecular Weight > 380 g/mol OR Group CNS log
Kow < 0.5 OR Group CNS Melting Point > 120 C OR Group CNS Melting Point
> 50 C OR Group CNS Molecular Weight > 620 g/mol by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "g"
Referential
boundary:The
target chemical should be classified as No alert found by Protein
binding alerts for skin sensitization by OASIS v1.4
Domain
logical expression index: "h"
Referential
boundary:The
target chemical should be classified as Acylation OR Acylation >> Ester
aminolysis OR Acylation >> Ester aminolysis >> Amides OR Nucleophilic
addition OR Nucleophilic addition >> Addition to carbon-hetero double
bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds
>> Ketones OR Schiff base formation OR Schiff base formation >>
Pyrazolones and Pyrazolidinones derivatives OR Schiff base formation >>
Pyrazolones and Pyrazolidinones derivatives >> Pyrazolones and
Pyrazolidinones OR SN1 OR SN1 >> Carbenium ion formation (enzymatic) OR
SN1 >> Carbenium ion formation (enzymatic) >> Carbenium ion OR SNAr OR
SNAr >> Nucleophilic aromatic substitution on activated aryl and
heteroaryl compounds OR SNAr >> Nucleophilic aromatic substitution on
activated aryl and heteroaryl compounds >> Activated aryl and heteroaryl
compounds by Protein binding alerts for skin sensitization by OASIS v1.4
Domain
logical expression index: "i"
Referential
boundary:The
target chemical should be classified as Aromatic Amine Type Compounds by
Oncologic Primary Classification
Domain
logical expression index: "j"
Referential
boundary:The
target chemical should be classified as Acyl and Benzoyl Type Compounds
OR Alpha-Haloalkylamine Reactive Functional Groups OR Carbamyl Halide
Type Compounds OR Halogenated Aromatic Hydrocarbon Type Compounds OR Not
classified OR Phenol Type Compounds OR Urea Type Compounds by Oncologic
Primary Classification
Domain
logical expression index: "k"
Referential
boundary:The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "l"
Referential
boundary:The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR SN2 OR SN2 >> SN2 reaction at
sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl diazo
by Protein binding by OECD
Domain
logical expression index: "m"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.79
Domain
logical expression index: "n"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 7.75
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
The skin irritation potential for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated using OECD QSAR toolbox version 3.4 The test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated to be not irritating to skin of New Zealand White rabbits.
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin irritation was estimated to be non-skin irritant on rabbits for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6). Thus it can be concluded that the substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6) has negative skin irritation effects.
A skin irritation study was conducted ((Scientific Committee on Cosmetology (seventh series), 1988))in rabbits to observe the irritation potential of the similar substance 129-17-9. 0. 5 ml of a saturated solution of the test chemical in saline was applied to rabbit skin (site not specified) and effects were observed (duration not specified). Hence Patent Blue V (CAS No: 129-17-9) was considered to be not irritating to rabbit skin.
The skin irritation test was conducted (SIDS Initial Assessment Report for SIAM 10 N-Isopropyl-N’-phenyl-p-phenylenediamine (IPPD)-OECD SIDS- Tokyo, 15-17 March 2000) on 6 rabbits to assess the irritation potential of the similar substance 101-72-4. In the study, 500 mg of IPPD was applied as a fine powder to the pre-moistened skin of 6 rabbits for 24 hours The animals were maintained for 7days and the scores for erythema and edema recorded at 4, 24, 48, 72 and 168 hours after removal of the dressing.
The scores were zero at all time points for all animals indicating that the test chemical, 4-(Isopropylamino) diphenylamine (CAS No: 101-72-4) is not a skin irritant in this study.
Based on the available information for the target and its read across substances and applying the weight of evidence of approach, Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl) was not irritating to skin.
Eye Irritation:
The ocular irritation potential of Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated using OECD QSAR toolbox v3.4
Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.
An eye irritation study was conducted ((Scientific Committee on Cosmetology (seventh series), 1988)) in rabbits to observe the irritation potential of the similar substance 129-17-9
0.25 ml of a saturated solution of the test chemical in saline was instilled into the eyes of rabbits and effects were observed (duration not specified). Patent Blue V (CAS: 129-17-9) was observed to be not irritating to rabbit eyes.
Study was conducted on similar substance 3844-45-9 by S.D. Gettings et al, 1992 to determine their ocular irritation potential.
Ocular irritation was determined according to a modification of the Draize test (Draize, 1959).FD&C Blue 1(CAS: 3844-45-9) was prepared daily as a 3% (w/v) suspension in aqueous vehicle containing 0.5% (w/v) hydroxypropyl methylcellulose and 0.25% (w/v) laureth -10 acetate.
FD&C Blue 1 (3% w/v in aqueous vehicle) was administered once daily, for a total of 21 days, to the conjunctival sac of the right eye of New Zealand White Rabbits (6 of each sex/ group) at a dose volume of 30µl. Control animals (6 of each sex) received 30/µl of the vehicle daily.Ocular irritation was determined according to a modification of the Draize test (Draize, 1959). Interpretation of observations and assignment of scores were consistent with those described by the Consumer Product Safety Commission (1972).All eyes were scored for ocular irritation pretest (8 days, 24 hr and immediately priorto the initial dose) and approximately 24 hr after each treatment, prior to the next instillation of test material; on days 1, 3, 7, 14 and 21, the eyes were also evaluated for irritation 1 hr after treatment. In addition, all readily observable ocular structures were evaluated for eye stain and particle embedment 24 hr after each treatment. All animals survived and were free of significant clinical signs of toxicity throughout the study. Ophthalmoscopic examinations revealed that all animals were free of abnormalities, all animals were free of significant signs of ocular irritation, staining and particle embedment. Thus it was considered that the test substance FD&C Blue 1 (Brilliant Blue FCF) was not irritating to eyes.
Based on the available data for the target as well as its read across chemicals and applying the weight of evidence approach, Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl can be considered as not irritating to eyes.
Justification for selection of skin irritation / corrosion endpoint:
data is from OECD QSAR toolbox v3.4
Justification for selection of eye irritation endpoint:
Data is from OECD QSAR toolbox v3.4
Justification for classification or non-classification
Available studies on Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl indicate that it is not likely to cause any irritation to eye and skin.
Hence, Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl can be evaluated as “Non- Irritant” to eyes and skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.