Registration Dossier
Registration Dossier
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EC number: 208-048-6 | CAS number: 506-64-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The EC50 for silver cyanide is predicted to be 0.00056 mg/L. Acute toxicity to Daphnia is predicted using a mixture toxicity approach, based on acute ecotoxicity data for silver and cyanide and speciation predictions for silver cyanide.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.001 mg/L
Additional information
In order to minimise the need for animal testing a calculation approach has been used in order to determine the acute toxicity of silver cyanide. As a large body of ecotoxicity data is already available for silver and cyanide, the toxicity of silver cyanide is predicted based on the measured values for silver and cyanide and the speciation of the precious metal cyanide substance in the test solution.
The results of the mixture toxicity assessment were validated using measured results for Daphnia. The modelled and measured EC50 values for toxicity of another substance containing silver and cyanide, potassium dicyanoargentate to Daphnia are in excellent agreement (0.0257 mg/L modelled, 0.022 mg/L measured) and therefore the predictions for acute toxicity for silver cyanide are considered to be reliable.
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