Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-305-9 | CAS number: 1555-58-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity data List V
- Author:
- Smyth Jr H.F., Carpenter C.P., Weil C.S., Pozzani U.C.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. 10, 61-68 (1954)
Materials and methods
- Principles of method if other than guideline:
- The acute concentrated vapor inhalation toxicity of the test substance was assessed using 6 male albino rats exposed to a flowing stream of air approaching saturation with vapors.
- GLP compliance:
- no
- Test type:
- concentration x time method
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-(methylimino)bispropiononitrile
- EC Number:
- 216-305-9
- EC Name:
- 3,3'-(methylimino)bispropiononitrile
- Cas Number:
- 1555-58-4
- Molecular formula:
- C7H11N3
- IUPAC Name:
- 3-[(2-cyanoethyl)(methyl)amino]propanenitrile
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name as used in publication: N-Methyl-3,3'-iminodipropionitrile
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- The stream to which the animals were exposed was prepared by passing dried air through a fritted disc gas washing bottle initialy at room temperature. When carbon dioxide reacts with the sample, the air stream is freed of that gas. Inhalations arecontinued for periods of time in an essentially logarithmic series with a ratio of two, extending to eight hours, until the period killing half the rats within 14 days of inhalation is defined.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Remarks on result:
- not determinable
- Mortality:
- No mortality occured after 8 hours exposure within the observation period of 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
