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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

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Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
16 259.31 mg/L
Remarks on result:
other: Estimated 96-h EC50 for Algae (ECOSAR v1.00a, Triazines)
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
43 018.31 mg/L
Remarks on result:
other: Estimated 96-h EC50 for Algae (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96 -h EC50 for Green algae is 2.188 mg/L (ECOSAR v1.00a, Triazines, Aromatic-acid). The estimated 96-h EC50 for green algae was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.
Executive summary:

The estimated 96 -h EC50 for Green algae is 2.188 mg/L (ECOSAR v1.00a, Triazines, Aromatic-acid). The estimated 96-h EC50 for green algae was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
8 618 mg/L
Remarks on result:
other: Estimated 96-h EC50 for Algae (ECOSAR v1.00a, Triazines)
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
22 560 mg/L
Remarks on result:
other: Estimated 96-h EC50 for Algae (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96 -h EC50 for Green algae is 2.188 mg/L (ECOSAR v1.00a, Triazines, Aromatic-acid). The estimated 96-h EC50 for green algae was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.
Executive summary:

The estimated 96 -h EC50 for Green algae is 2.188 mg/L (ECOSAR v1.00a, Triazines, Aromatic-acid). The estimated 96-h EC50 for green algae was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
4 560.45 mg/L
Remarks on result:
other: Estimated 96-h EC50 for Algae (ECOSAR v1.00a, Triazines)
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
11 810.36 mg/L
Remarks on result:
other: Estimated 96-h EC50 for Algae (ECOSAR v1.00a, Baseline toxicity)
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96 -h EC50 for Green algae is 2.188 mg/L (ECOSAR v1.00a, Triazines, Aromatic-acid). The estimated 96-h EC50 for green algae was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.
Executive summary:

The estimated 96 -h EC50 for Green algae is 2.188 mg/L (ECOSAR v1.00a, Triazines, Aromatic-acid). The estimated 96-h EC50 for green algae was much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.

Description of key information

Weight of evidence: ECOSAR v1.00a for Triazines and Baseline toxicity. The estimated 96-h EC50 for green algae for the three constituents of the test item, were found to be much higher than 100 mg/L.


Supporting study: Read-across from experimental data on P0310. Test method OECD 201. GLP study. The 72-hour NOEC and the 72-hour EC0 to Pseudokirchneriella subcapitata were determined to be 100 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:
100 mg/L
EC10 or NOEC for freshwater algae:
100 mg/L

Additional information

Weight of evidence: The estimated 96-h EC50 for green algae for the three constituents of the test item, were found to be much higher than 100 mg/L based on ECOSAR v1.00a models for Triazines and Baseline toxicity.

Supporting study: Based on the read-across approach from experimental data on the analogue P0310 (OECD Guideline 201, GLP study), the 72-hour NOEC and the 72-hour EC0 to Pseudokirchneriella subcapitata were determined to be 100 mg/L (mean measured concentration of 26 mg/L).