Registration Dossier
Registration Dossier
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EC number: 292-054-9 | CAS number: 90530-16-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR and read-across: TIMES AOT model and TB read-across predictions
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- EC Number:
- 292-054-9
- EC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
- Cas Number:
- 90530-16-8
- IUPAC Name:
- 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine
Constituent 1
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 917 mg/kg bw
- Based on:
- other: QSAR and read-across
- Remarks on result:
- other: QSAR read-across
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information H302 Criteria used for interpretation of results: EU
- Conclusions:
- • Documented data is only found for constituent MXDA: in vivo LD50 data: 929 mg/kg (category 4 according to the CLP/GHS classification). This is supported by the TIMES AOT model and TB read across predictions. The experimental and predicted data fall into the same toxic category.
• Based on TIMES AOT model and TB read-across predictions:
o Constituents A and C are predicted to belong to hazard category 4 according to CLP/GHS classification.
o Constituents B, D and E are GHS hazard category 5/ CLP not classified.
• The predicted acute oral toxicity of UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine (CAS RN: 90530-16-8) is 917 mg/kg (CLP/GHS hazard category 4). - Executive summary:
The predicted acute oral toxicity of UVCB 2-Propenenitrile, reaction products with 1,3-benzenedimethanamine (CAS RN: 90530-16-8) is 917 mg/kg (CLP/GHS hazard category 4: H302)
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