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EC number: 246-730-5 | CAS number: 25198-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- May 29, 1998
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- No information on the composition is available
- Principles of method if other than guideline:
- Only short abstract available. No information about guideline followed.
- GLP compliance:
- not specified
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 35 mg/L
- Conclusions:
- LC50 = 35 mg/l
- Executive summary:
Method
The test on was conducted with an unspecified method. Only short abstract is available for this study.
Conclusion
LC50 = 35 mg/l
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- From November 23 to 27, 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- The test was conducted on a similar substance. Further details were reported in the attachment at section 13.
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38 412 "TESTVERFAHREN MIT WASSERORGANISMEN (GRUPPE L). ALLGEMEINE HINWEISE ZUR PLANUNG, DURCHFUEHRUNG UND AUSWERTUNG BIOLOGISCHER TESTVERFAHREN (Ll)"
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: "BESTIMMUNG DER WIRKUNG VON WASSERINHALTSSTOFFEN AUF FISCHE - FISCHTEST (L15)", JUNE 1982.
- Deviations:
- not specified
- GLP compliance:
- no
- Details on sampling:
- - Concentrations: 10.0, 21.5, 46.4 and 100 mg/l.
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Preparation of the test substance: The product was added to the test water without any pretreatment; subsequently the fish were placed into the aquaria.
- Reasons for the selection of the concentrations: based on the results of 2 range finding studies and 1 main study not evaluated (LC50 after 96 h: between 32 and 100 mg/l). - Test organisms (species):
- other: Leuciscus idus l., golden variety
- Details on test organisms:
- TEST ORGANISM
- Common name: Golden Orfe
- Strain: Leuciscus Idus L., Golden Variety
- Source: Fischzucht Paul Eggers D-2354 Hohenwestedt, Frg
- Length at study initiation: 5.3 Cm (Range: 4.7 - 5.7)
- Weight at study initiation: 3.7 G (Range: 2.1 - 4.9)
- Food type: Growing Feed F/B 50 Ssniff Spezialdiaeten Gmbh D-4770 Soest, Frg ad Libitum
ACCLIMATION
- Acclimation period: about 8 Weeks
OTHER CONDITIONS
- Water Temperature: 20 Centigrade +-1
- Medical Treatment: Twice With 0.05 Mg/L Malachite Green Chloride
- Housing: The fish were kept in a flow-through tank in tap water cleaned by active carbon and aerated with oil-free air.
- Mortality during the last 2 weeks of housing: about 0.2%
- Mortality during the adaptation period: 0%
- Medical Treatment: twice with 0.05 mg/l malachite green chloride once with 10 mg/l tetracycline hydrochloride - Details on test conditions:
- TEST SYSTEM
- Test vessel: All-glass aquarium (30 cm x 22 cm x 24 cm)
- Aeration: continuous aeration with oil-free air
- No. of organisms per test concentrations: 10
- Loading (g fish / l test water): 3.7
- Adaptation to test water and test temperature: 3 days
- Withdrawel of food before exposure: 1 day
TEST MEDIUM / WATER PARAMETERS
- Test Water: reconstituted freshwater according to din 38 412, part 11, draft sept. 198].preparation from fully demineralized tap water conductivity: max. 10 micro mho
- Total Hardness : about 2.5 mmol/l
- Acid Capacity : about 5.5 mmol/l
- Ratio Ca/Mg Ions : 4 :1
- Ratio Na/K Ions : 10: 1
- Oxygen Content : > 60% of maximum saturation
- Test Medium:
294.0 mg/l CaCl2 . 2 H2O
123.3 mg/l MgSO4 .7 H2O
64.8 mg/l NaHCO3
5.8 mg/l KCl
OTHER TEST CONDITIONS
- pH : about 8.0
- Photoperiod: 16 hours light and 8 hours dark - Reference substance (positive control):
- yes
- Remarks:
- Chloroacetamide
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 46.4 - < 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- LC50 (48 h)= about 26 mg/l
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 46.4 mg/l
- Executive summary:
Method
The short-term toxicity to fish was determined according to DIN 38 412 "Testverfahren mit wasserorganismen (gruppe l). allgemeine hinweise zur planung, durchfuehrung und auswertung biologischer testverfahren (ll)". The test was conducted at four different concentration: 10.0, 21.5, 46.4 and 100 mg/l.
Conclusion
46.4 mg/l <LC50< 100 mg/l
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- March 25, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Internal Method 11
- GLP compliance:
- no
- Test organisms (species):
- other: Trout
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 45 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 = 45 mg/l
- Executive summary:
Only short abstarct is available. The LC50 value calculated in this test was 45 mg/l.
Referenceopen allclose all
Description of key information
LC50 = 35 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 35 mg/L
Additional information
The substance was tested in order to evaluate the short-term toxicity to fish. No information about the method used for the execution of the study is available. The LC50 value calculated was 35 mg/l.
To support this information a test on an analogue molecule, with a different salification of the same core structure (Similar Substance 01) is available. Further information are reported in the Read Across justification attached to section 13.
The test on the Similar Substance 01 was determined according to DIN 38 412 "Testverfahren mit wasserorganismen (gruppe l). allgemeine hinweise zur planung, durchfuehrung und auswertung biologischer testverfahren (ll)". The test was conducted at four different concentrations: 10.0, 21.5, 46.4 and 100 mg/l. The LC50 value calculated for this test was in a range of 46.4 mg/l and 100 mg/l.
This result is in line with a further test on the Similar Substance 01, where the LC50 value calculated was 45 mg/l.
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