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EC number: 215-925-7 | CAS number: 1453-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-02-15 - 1984-03-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No bodyweights are reported.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 205 (Avian Dietary Toxicity Test)
- Deviations:
- yes
- Remarks:
- no bodyweights are reported
- GLP compliance:
- no
- Dose method:
- feed
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on preparation and analysis of diet:
- vehicle: sunflower oil
- Test organisms (species):
- Coturnix coturnix japonica
- Details on test organisms:
- Wild-coloured Japanese quails from the random breeding of the Ornithological Research Centre Seebach were used without sex differentiation at the age of 11 days.
- Limit test:
- no
- Total exposure duration (if not single dose):
- 5 d
- No. of animals per sex per dose and/or stage:
- 10 animals per dose
- Control animals:
- yes, plain diet
- Nominal and measured doses / concentrations:
- Nominal: 5000 mg/kg diet
- Details on test conditions:
- The test substance was mixed into the feed (turkey fattening feed) with the addition of 20 g sunflower oil per kg. The test substance was applied to the feed over a period of 5 days.
- Reference substance (positive control):
- no
- Key result
- Duration (if not single dose):
- 5 d
- Dose descriptor:
- LC50
- Effect level:
- > 5 000 mg/kg diet
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Further details on results:
- The test animals showed delayed growth.The intake of the test food by the test animals was reduced.
Symptomatology: The treatment was tolerated without symptoms.
Lethality: No test animal died. - Validity criteria fulfilled:
- yes
- Conclusions:
- The acute oral LD50 of 3-Methylpyrazol to japanese quails is > 5000 mg/kg diet.
- Executive summary:
The acute oral LD50 of 3-Methylpyrazol to japanese quails is > 5000 mg/kg diet.
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No body weights are reported in the test report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 223 (Avian Acute Oral Toxicity Test)
- Deviations:
- yes
- Remarks:
- no body weights are reported
- GLP compliance:
- no
- Dose method:
- gavage
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on preparation and analysis of diet:
- vehicle: water
- Test organisms (species):
- Coturnix coturnix japonica
- Details on test organisms:
- Japanese quail female. Age 32 weeks, from random breeding at the Ornithological Research Centre Seebach. The average body mass at the start of the experiment was 121.7 ± 13.7 g.
- Limit test:
- no
- Total exposure duration (if not single dose):
- 1 d
- Post exposure observation period:
- 14 days
- No. of animals per sex per dose and/or stage:
- 5 animals per dose
- Control animals:
- no
- Nominal and measured doses / concentrations:
- 5 logarithmically graded dose groups of 5 animals each in the dose range from 385 to 1098 mg/kg body mass, progressor 1.3.
- Details on test conditions:
- The test substance dissolved in water was administered once in graduated concentrations in a volume of 1 ml liquid per 100 g body mass Japan quail. The application was carried out by means of a rigid gavage.
- Reference substance (positive control):
- no
- Key result
- Duration (if not single dose):
- 1 d
- Dose descriptor:
- LD50
- Effect level:
- 515 mg/kg bw
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Mortality and sub-lethal effects:
- Ruffled plumage, weakness, lateral recumbency, ataxia (turning movements, head turning), apathy, sometimes increased salivation, wing tremor. Exitus occurred after 2 hours to 5 days after application.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute oral toxicity LD50 of 3-Methylpyrazol to Japanese quails is 515 mg/kg bodyweight.
- Executive summary:
The acute oral toxicity of 3-Methylpyrazol to 32 weeks old Japanese quails was assessed over 14 days similar to OECD 205. Test material was administered as a single dose to the birds by gavage at 385-1098 mg ai/kg bw. The acute oral LD50was 515 mg ai/kg bw.
Referenceopen allclose all
Description of key information
Short-term toxicity to Coturnix cotirnix japonica
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 5 000 mg/kg food
Additional information
5000 mg/kg food was the highest tested dose. Since no effects were observed, the LD50 does exceed this value by far, nevertheless the exposure assessment is performed using this figure as worst case scenario.
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