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EC number: 259-411-0 | CAS number: 54959-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to methods similar to OECD471, non-GLP. However the reporting of results for EDTA-FeNa is limited.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity of Iron Compounds in Salmonella fyphimurium and L5 178Y Mouse Lymphoma Cells
- Author:
- Dunkel VC, San RHC, Seifried HE, Whittaker P
- Year:
- 1 999
- Bibliographic source:
- Environ Mol Mutagen 33: 28-41
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- other: Ames te al. 1975 and Yahagi et al. 1977
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium feredetate
- EC Number:
- 239-802-2
- EC Name:
- Sodium feredetate
- Cas Number:
- 15708-41-5
- Molecular formula:
- C10H12N2O8FeNa
- IUPAC Name:
- Sodium; 2-[2-(bis(carboxylatomethyl)amino)ethyl-(carboxylatomethyl)amino]acetate; iron(+3) cation
- Details on test material:
- Substance: Sodium iron (III) EDTA
Molecular formula: NaFeEDTA (Hamp-ene, 13% Fe)
Purity: 98%
Supplier: W.R. Grace & Co.
Constituent 1
Method
- Target gene:
- Histidine operon
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 102
- Species / strain / cell type:
- S. typhimurium, other: TA 97a
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- up to 10,000 µg/Fe plate = 75,397.76 µg EDTA-FeNa/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: distilled water
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- distilled water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation) and preincubation
DURATION
- Preincubation period: 20 minutes
- Exposure duration: 48 hours
SELECTION AGENT (mutation assays): histidine
NUMBER OF REPLICATIONS: triplicate
NUMBER OF CELLS EVALUATED: all plates were examined for revertant colonies
DETERMINATION OF CYTOTOXICITY
- Method: growth rate - Evaluation criteria:
- The criteria used to evaluate a test stipulated that a test article must induce at least a doubling in the mean number of revertants per plate of at least
one tester strain (TA97a, TA98, TA100, TA102, and TA1535) for it to be considered positive. This increase in the mean revel (ants per plate must be accompanied by a dose response to increasing concencmtions of the test chemical. If the stody shows a dose-response, but with a less than 3-fold increase on TA1537 or TA1538, the response must be confirmed in it repeat experiment. - Statistics:
- Not applicable
Results and discussion
Test results
- Species / strain:
- other: all strains tested
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- No data
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
EDTA-FeNa tested up to 10,000 µg/plate Fe in the plate incorporation and pre-incubation Ames test dit not result in an increased number of revertant colonies in strains S. typhimurium strains TA 98, 97a., 100, 102, 1537, 1538. - Executive summary:
EDTA-FeNa tested up to 10,000 µg/plate Fe in the plate incorporation and pre-incubation Ames test dit not result in increased number of revertant colonies in strains S. typhimurium strains TA 98, 97a., 100, 102, 1537, 1538.
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