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Diss Factsheets
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EC number: 202-870-9 | CAS number: 100-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Information is insufficient to assess the carcinogenicity capacity of N-methylaniline.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- Data from Scientific Commitee on Occupational Exposure Limit (SCOEL)
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Information is insufficient to assess the carcinogenicity capacity of N-methylaniline. N-methylaniline is not classified for carcinogenicity according to annex VI of CLP Regulation (EC n.1272/2008).
Additional information
As indicated in SCOEL/SUM/178 of December 2012 for N-methylaniline information is insufficient to assess the carcinogenic and reprotoxic capacity of N-methylaniline. However, two main studies are reported by SCOEL.
In the first one (see White et all, J NatI Cancer Inst 12:777-787, 1952) haemorrhagic foci in the liver, but no tumours in this or any other organ were found in 20 male and 20 female Osborne-Mendel rats after oral treatment with 0.06 % N-methylaniline hydrochloride in food for a period of 272–758 days. No control group was described in this study.
In the second one (see Greenblatt et all, J Natl Cancer Inst 46:1029-1034, 1971), 20 male and 20 female Swiss mice received N-methylaniline in food (1950 mg/kg food) for 28 weeks followed by a posttreatment period of 12 weeks. The incidence of lung adenomas in the N-methylaniline-treated group was not different from control data. No other tumours were observed .Because of the short exposure period, small group size, and absence of control group in the rat study, no definite conclusions can be drawn from these results.
As a secondary amine, N-methylaniline may be converted to the corresponding N-nitroso compound under certain conditions. Many of these N-nitrosoamines are mutagenic. Corresponding data on the mutagenicity of N-nitroso-N-methylamine were not available. The incidence of lung adenomas was increased significantly when the N-methylaniline treated animals also received sodium nitrite (NaNO2) at 0.1 % in drinking water 5 times/week . It was concluded that carcinogenic nitrosamines were formed from N-methylaniline in vivo.
Justification for selection of carcinogenicity via oral route endpoint:
Adverse effect observed but information is insufficient to assess the carcinogenicity capacity of N-methylaniline
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