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Diss Factsheets
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EC number: 202-870-9 | CAS number: 100-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro studies
As reported in SCOEL/SUM/178 of December 2012 for N-methylaniline with reference to CCRIS Chemical Carcinogenesis Research Information system, N-methylanile published online (http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~mYKzKq:4), update 2006 N-methylaniline was not mutagenic in Ames tests with Salmonella typhimurium strains in the absence or presence of S9 mix from different species (Note: online CCRIS refers to Zeiger et all, Environ. Mol. Mutagen. 11(Suppl.12):1-158, 1988). N-methylaniline did not induce unscheduled DNA-synthesis in primary cultures of rat hepatocytes (see online CCRIS with reference to Yoshimi et all, Mutat. Res. 206(2):183-191, 1988). The only positive study regarding genotoxicity of N-methylaniline is reported by NIHS Japan 2010: N-methylaniline induced structural chromosomal aberrations including gaps, but no polyploidy in Chinese hamster lung cells in the absence (no cytotoxicity) and in the presence (about 50 % growth inhibition) of exogenous metabolic activation.
In vivo studies
There were no data available
Conclusion
Based on these results, N-methylaniline was not mutagenic: only one study of chromosomal aberrations is positive but all other in vitro studies are negative. Moreover, N-methylaniline is not classified for genetic toxicity according to annex VI of CLP Regulation (EC n.1272/2008).
Justification for selection of genetic toxicity endpoint
Data from reliable source (Scientific Commitee on Occupational Exposure Limit SCOEL)
Short description of key information:
No genetic toxicity for N-methylaniline (only chromosomal aberration positive but all the others studies are negative).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on these results, N-methylaniline was not mutagenic: only one study of chromosomal aberrations is positive but all other in vitro studies are negative.
Moreover, N-methylaniline is not classified for genetic toxicity according to annex VI of CLP Regulation (EC n.1272/2008).
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