3-dimethylaminopropiononitrile

Endpoint summary

Additional information

Acute toxicity to fish:

The key study concerning the short-term toxicity of 3 -dimethylaminopropiononitrile (CAS 1738 -25 -6) to fish was performed as a guideline study according to DIN 38412 Part 15 with the test species Leuciscus idus (BASF AG, 1989, report no. 10F0143/885226).

The LC50 based on nominal test item concentrations was determined to be 681.2 mg/L (calculated as geometrical mean). At a test concentration of 464 mg/L no fish died, whereas a 100% mortality was observed in the next higher tested concentration of 1000 mg/L.

Long-term toxicity to fish:

There are no valid long-term toxicity results for fish available. Fish are not the most sensitive organisms. Therefore and for reasons of animal welfare, a long-term toxicity study in fish is not provided.

Acute toxicity to aquatic invertebrates:

An acute toxicity study was performed with Daphnia magna according to EU Method C.2 (BASF AG 1988, report no. 1/0947/2/88 -0947/88).

The reported nominal 48 -h EC₅₀of the test substance on Daphnia magna was > 500 mg/L. This was the highest tested concentration and only 4 out of 20 animals were immobilized. Therefore, 3 -dimethylaminopropionitrile is considered to be with high probability acutely not harmful to aquatic invertebrates.

Long-term toxicity to aquatic invertebrates:

The hazard assessment of 3-dimethylaminopropiononitrile (CAS 1738-25-6) reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore long-term toxicity testing on invertebrates is not provided.

Toxicity to aquatic algae:

In a 72-hour static test with the green alga Scenedesmus subspicatus according to the German Industrial Standard Test Guideline DIN 38412, the toxicity of 3 -dimethylaminopropionitrile in algae was investigated (BASF, 1989, report no. 01/88/0947). After 72 hours an EC50 of > 500 mg/L and an EC10 of 30.3 mg/L was estimated for the growth rate, related to the nominal concentration. Concerning observations of the biomass, the values are: EbC10 (72h): 10.2 mg/L, EbC50 (72h): 209.1 mg/L.

Toxicity to aquatic microorganisms:

As key study a non-GLP test according to German Industrial Standard DIN 38412 was performed using Pseudomonas putida as test organism. The EC10 (17h) was estimated to be 3432 mg/L and the EC50 was 4733 mg/L, both related to the nominal concentration (BASF AG 1989, report no. 9/0947/88/w). In addition, a respiration inhibition test according to ISO 8192 was conducted (BASF AG 1988, report no. 01.102). The EC10 (30 min) was determined to be > 1000 mg/L. However, the test was performed using industrial activated sludge and can therefore not be used for the derivation of the PNECstp.