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EC number: 810-816-6 | CAS number: 1473386-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): According to the results of preliminary test, the test substance was not soluble in water, but was soluble in a acetone. The test substance was added into the test system by the test substance solvent stock solution.
An aliquot solvent solution was separately added to about 10g silica sand and the solvent allowed to evaporate off prior to incorporation into formulated artificial soil with deionized reverse osmosis water. These were mixed by a mixer to give the blank control, solvent control, 10, 100 and 1000 mg/kg respectively with a nominal moisture content of 40-60% by mass of the total water-holding capacity with the deionized water. The test medium preparation process of the blank control group was same as the other groups, but without the solvent and the test substance. The test medium preparation process of the solvent control group was same as the other groups, but without the test substance.
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: erthworms
- Source: Jiang Su province Jurong Stock Farm. (ID: EF-MKT-170905)
- Age at test initiation (mean and range, SD): adult earthworms
- Weight at test initiation (mean and range, SD): 300 - 600 mg
ACCLIMATION
- Acclimation period: 24 hours
- Acclimation conditions (same as test or not): same - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 19.8°C to 20.2°C
- pH:
- 6.0±0.5
- Moisture:
- 40-60% water content
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1L breathable glass bottle
- Amount of soil or substrate: 750 g wt (artificial soil)
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Soil texture (if natural soil)
- 10% w/w Sphagnum peat
- 20% w/w Kaolinite clay (Sigma-Aldrich)
- 70% w/w Silica sand (screened with 0.2 mm sieve)
OTHER TEST CONDITIONS
- Photoperiod: continuous illumination
- Light intensity: 607 - 621 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality after 7 and 14 days
- Nominal and measured concentrations:
- 10, 100 and 1000 mg/kg (range finding)
1000 mg/kg main test - Reference substance (positive control):
- yes
- Remarks:
- chloroacetamide
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - The mortalities in the blank control group and the solvent control group were both 7.5%. Thus, the test fullfills the validity criterion that control mortality should not exceed 10%.
- No adverse behavioural effects were observed at either 7 or 14 days exposure in any of the treatment groups. - Validity criteria fulfilled:
- yes
- Conclusions:
- Expressed as nominal concentration, the median lethal concentration of C 17 Acrylate on Eisenia fetida are as follows:
The 7 day LC50 value was higher than 1000 mg/kg dry soil weight and the 14 day LC50 value was higher than 1000 mg/kg dry soil weight.
Reference
Description of key information
The 7-Day LC50and the 14-Day LC50for the test substance to earthworms (Eisenia fetida) based on the nominal test concentrations were both higher than 1000mg/kg dry soil weight.
Key value for chemical safety assessment
Additional information
The acute toxicity of the test substance C 17 Acrylate to Eisenia fetida was determined in a 14 days artificial soil test (OECD Guideline, 207 Earthworm, Acute Toxicity Test). Based on the results of range-finding test, one blank control group, one solvent control group and one treatment group which had four replicates of 10 worms per replicate were included in the limit test. The nominal concentration of the treatment group was1000 mg/kg dry artificial soil weight. The number of mortalities were determined after 7 and 14 days exposure. The mortality of the earthworm in the blank control group was 7.5%, in the solvent control group was 7.5%, which were not more than 10 per cent, so the test was valid. Under the tested conditions, the 7-Day LC50 and the 14-Day LC50 for the test substance to earthworms (Eisenia fetida) based on the nominal test concentrations were both higher than 1000 mg/kg dry soil weight.
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