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Diss Factsheets
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EC number: 810-533-8 | CAS number: 330459-31-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Under the test conditions, the test substance was well absorbed following oral administration to rats. It was extensively metabolized and rapidly excreted, primarily via the bile and faeces, with little tissue retention. Major routes of metabolism of the test substance in rats were oxidation (hydroxylation) of the thiophene ring, followed by conjugation primarily with glucuronic acid, and reductive cleavage and subsequent hydrolysis of the oxadiazole ring.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
A study was performed to determine the pharmacokinetics, routes of elimination, mass balance, tissue distribution, and metabolite profiles of [14C] labeled residues after oral or intravenous administration of [phenyl (PH)-UL-14C] labeled test substance or [thiophene (TH)-2 -14C] labeled test substance at dose 3 and 100 mg/kg bw to rats, according to OECD Guideline 417 and OPPTS 870.7485, in compliance with GLP.This study was conducted in multiple phases: a pilot phase, a pharmacokinetic phase, a disposition and metabolite identification phase, and a quantitative whole body autoradiography (QWBA) phase. Also, major metabolites of these compounds were quantified and identified or characterized to the extent possible using LC/MS/MS.The test substance was well absorbed following oral administration to rats. It was extensively metabolized and rapidly excreted, primarily via the bile and faeces, with little tissue retention. There may have been a slight increase in relative plasma levels of the test substance and/or its metabolites after dosing at 100 mg/kg bw vs. 3 mg/kg bw but there were no major differences in excretion or metabolism due to route of administration, dose level, sex of the animals, or single vs. repeat dosing. Major routes of metabolism of the test substance in rats were oxidation (hydroxylation) of the thiophene ring, followed by conjugation primarily with glucuronic acid, and reductive cleavage and subsequent hydrolysis of the oxadiazole ring (Thomas J, 2014).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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