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EC number: 211-637-0 | CAS number: 677-21-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
In a 4-week rat inhalation study performed according to OECD Guideline 412 at concentrations of 500, 1500, 5000, and 15000 ppm, no NOAEC was observed (LOAEC of 500 ppm) based on myocardial vacuolation and focal and multifocal mononuclear cell infiltrate ascribed to a direct toxic effect on the myocardial fibers and to the effects on blood vasculature, respectively (TNO, 2010).Additionally in a second 4-week rat inhalation study (Huntingdon Life Sciences, 2010). performed according to Guideline 412 at measured concentrations of 4967, 14953, and 49686 ppm, no NOEC was determined based on myocardial vacuolation/myofibre degeneration in all groups. Myocardial fibrosis and myocardial congestion (males) was observed at 14593 and 49686 ppm. Therefore, the test substance is classified as as Xn; R48/20 (Harmful: danger of serious damage to health by prolonged exposure through inhalation) according to EU Directive 67/548/EEC and STOT Rep Exp. 2 (H373: May cause damage to organs [blood vessels; heart] through prolonged or repeated inhalation exposure) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
References:
TNO (2010). A sub-acute (28-day) inhalation toxicity study with 3,3,3-trifluoroprop-1-ene (HFO-1243zf) in rats. Unpublished data, TNO Report No. V8668, A sub-acute (28-day) inhalation toxicity study with 3,3,3-trifluoroprop-1-ene (HFO 1243zf) in rats (December 3); TSCA Section 8e submission, 8EHQ-0111-17890C.
Huntingdon Life Sciences (2010). Unpublished data, HLS study number AST0031. 3,3,3-Trifluoroprop-1-ene (HFO 1234zf): Toxicity study by inhalation administration to CD rats for 4 weeks (November 2010); cited in TSCA 8e submission, 8EHQ-09-17629.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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