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EC number: 239-263-3 | CAS number: 15206-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register 38, No. 187, §1500.41, S. 27029
- Version / remarks:
- 1973
- Deviations:
- yes
- Remarks:
- Exposure period extended to 24 hours, no scoring at 48 hour observation, and observation period shortened to 8 days.
- Principles of method if other than guideline:
- 2 animals were tested applying the test substance for 5 min and 2 hours under occlusive conditions, respectively. The test substance was rinsed with Lutrol and observed after 24, 48 hours and 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl benzoylformate
- EC Number:
- 239-263-3
- EC Name:
- Methyl benzoylformate
- Cas Number:
- 15206-55-0
- Molecular formula:
- C9H8O3
- IUPAC Name:
- methyl oxo(phenyl)acetate
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean: female: 3.44 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 5min, 2h or 24 hours
- Observation period:
- 24, 72 hours and 8 days
- Number of animals:
- 3 (24h exposures)
2 (5min and 2h exposure) - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 1
- Time point:
- other: 24, 72 hours
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: intact skin (24h exposure), 48h reading was not taken due to study design and age of the study.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 1
- Time point:
- other: 24, 72 hours
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: intact skin (24h exposure), 48h reading was not taken due to study design and age of the study.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 2
- Time point:
- other: 24, 72 hours
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: intact skin (24h exposure), 48h reading was not taken due to study design and age of the study.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 2
- Time point:
- other: 24, 72 hours
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: intact skin (24h exposure), 48h reading was not taken due to study design and age of the study.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 3
- Time point:
- other: 24h, 72 hours
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: intact skin (24h exposure), 48h reading was not taken due to study design and age of the study.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 3
- Time point:
- other: 24, 72 hours
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: intact skin (2h exposure), 48h reading was not taken due to study design and age of the study.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 4
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 2 hour exposure, 72h reading was not taken due to study design and age of the study.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 4
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: 2 hour exposure, 72h reading was not taken due to study design and age of the study.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 5
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 2 hour exposure, 72h reading was not taken due to study design and age of the study.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 5
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: 2 hour exposure, 72h reading was not taken due to study design and age of the study.
- Other effects:
- Scaling was found in all animals on day 8 of observation.
Any other information on results incl. tables
Results for 24h exposure:
|
reading time |
animal 1 |
animal 2 |
animal 3 |
erythema |
|
|
|
|
intact skin |
24h |
2 |
2 |
2 |
|
72h |
3 |
2 |
3 |
|
8d |
2 S |
0 S |
2 S o |
|
mean 24,72h |
2.5 |
2 |
2.5 |
abraded skin |
24 h |
3 |
3 |
2 |
|
72h |
3 |
3 |
3 o |
|
8d |
2 S |
1 S |
2 sS o |
|
mean 24,72h |
3 |
3 |
2.5 |
edema |
|
|
|
|
intact skin |
24 h |
2 |
0 |
2 |
|
72h |
2 |
1 |
2 |
|
8d |
0 |
0 |
0 |
|
mean 24,72h |
2 |
0.5 |
2 |
abraded skin |
24 h |
2 |
2 |
2 |
|
72h |
3 |
3 |
3 o |
|
8d |
0 |
0 |
0 |
|
mean 24,72h |
2.5 |
2.5 |
2.5 |
S: scaling; sS: strong scaling; overall
Results for internal method: After 2 hour exposure with the test substance to the skin of two rabbits erythema of score 1 was observed 24 hours later. This effect was fully reversible within 48 hours (score 0). 8 days after application scaling was still observed. No edema was observed at any reading time point.
Exposure Time | Animal No. | 1. Redness - Corossion | 2. Oedema | ||||
24 hrs | 48 hrs | 8 Days | 24 hrs | 48 hrs | 8 Days | ||
2 hrs | 1 | 1 | 0 | 0 S | 0 | 0 | 0 |
2 | 1 | 0 | 0 S | 0 | 0 | 0 |
S = scaling
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material achieved mean erythema scores in 2 of 3 test animals of 2.5 each after a 24 hour occlusive exposure. After a 2 hour expsoure the test material achieved a mean erythema score of 0.5 in both animals tested, fully reversible within 8 days. Due to the non-standard exposure period, the test material is considered not to fulfill the criteria for skin irritation under EU regulation 12772/2008.
- Executive summary:
In this guideline study (Federal Register 38, No. 187, §1500.41, S. 27029; 1973) the test material was tested twice with exposure times of 24 hours and 2 hours. After the 24 hour exposure period, the test material achieved mean erythema scores in 2 of 3 animals of 2.5 each. After the 2 hour exposure, the test material achieved a mean erythema scores in both test animals of 0.5, reversible in 8 days. As the standard exposure period is 4 hours, the test material is considered not to meet the criteria cor skin irritation classificaiton according to EU Classification, Labelling, and Packaging (CLP) regulation (1272/2008).
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