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EC number: 239-263-3 | CAS number: 15206-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl benzoylformate
- EC Number:
- 239-263-3
- EC Name:
- Methyl benzoylformate
- Cas Number:
- 15206-55-0
- Molecular formula:
- C9H8O3
- IUPAC Name:
- methyl oxo(phenyl)acetate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany
- Age at study initiation: male animals approx. 8 - 10 weeks, female animals approx. 12 - 14 weeks
- Weight at study initiation: 200-300g
- Housing: singly
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5d
- Fasting: 16h before administration
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal and dorsolaterale parts of the trunk
- % coverage: 10
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing of the application site with luke warm water
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.75 ml/kg bw
- Concentration (if solution): 100%
- Constant volume or concentration used: yes
For a better homogeneity the test item will be heated at 40°C for approx. 1 hour. The test item will be administrated hand warm. - Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals will be observed individually for behaviour changes or signs of toxicity <0.5, 1, 2, 3, 4 and 5 hours after dosing at the day of administration and at least once daily thereafter. Clinical observations will be performed at least once each working-day and recorded individually. Individual body weight will be determined shortly before test item administration, at weekly intervals thereafter and before the sacrifice of the animals at the end of the observation period. Moreover, the body weights of animals that die or are sacrificed in a moribund state will be determined from study day 1, onward. A check for moribund and dead animals will be made at least once each workday.
- scoring: Individual recording of findings 30 - 60 minutes after removal of the semi- occlusive dressing; afterward, at approx. weekly intervals and on the last day of observation.
- Necropsy of survivors performed: yes
- Other examinations performed: On the last day of the observation period, the animals will be sacrificed by CO2-inhalation in a chamber with increasing concentrations over time, followed by necropsy and gross-pathological examination. All animals that die will be necropsied as early as possible after death. - Statistics:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No systemic clinical signs were observed during clinical examination.
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals examined at the end of the study.
- Other findings:
- In all male animals well-defined erythema (grade 2) was noted on study day 1 and persisted in four of these animals until study day 3. Thereafter, very slight erythema (grade 1) was noted in these four animals from study day 6 until study day 7 or 8. In the fifth animal very slight erythema was seen from day 2 until day 8. Very slight edema (grade 1) was noted in all male animals on study day 1 only. Scaling was noted in three male animals from study day 7 or 8 until study day 10 after application.
In two females well-defined erythema (grade 2) was noted on study day 1, but decreased to very slight erythema (grade 1) in one of these animals and was noted from study day 2 until study day 7. In these two females very slight edema (grade 1) was seen on study day 1 after application only.
In the three remaining female animals very slight erythema (grade 1) was noted on study day 1, only.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material has an LD50 of >2000 mg/kg bw for acute dermal toxicity. This test value does not fulfill the criteria for classification and labelling according to EU regulation 1272/2008.
- Executive summary:
In this guideline study (OECD 403) conducted with GLP certification, the acute dermal LD50 of the test material (EC 239-263-3) was determined to be >2000 mg/kg bw in the Rat. Test animals were exposed for 24 hours with a semiocclusive bandage. The test material was administered unchanged. The test material is not classified as acutely toxic according to the EU Classification, Labelling, and Packaging (CLP) regulation (1272/2008), based upon this result.
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