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EC number: 216-125-0 | CAS number: 1503-48-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Qualitative descripton of effects observed in a single animal. Little information on test item and animals.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 2 animals only, one with flushed eye 30 seconds after treatment. Qualitative description of effects.
- GLP compliance:
- no
Test material
- Reference substance name:
- Quino[2,3-b]acridine-6,7,13,14(5H,12H)-tetrone
- EC Number:
- 216-125-0
- EC Name:
- Quino[2,3-b]acridine-6,7,13,14(5H,12H)-tetrone
- Cas Number:
- 1503-48-6
- Molecular formula:
- C20H10N2O4
- IUPAC Name:
- quino[2,3-b]acridine-6,7,13,14(5H,12H)-tetrone
- Details on test material:
- purity: 98.8%
name in report: Quinacridonequinone, QAQ
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino, unspecified
- Details on test animals or tissues and environmental conditions:
- No data reported
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0,1 ml (17.76 mg)
- Duration of treatment / exposure:
- single treatment
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 1 with flushed eye 30 seconds after treatment
1 without flushing - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): flushing with tap water for one of the two animals
- Time after start of exposure: 30 seconds
SCORING SYSTEM: qualitative description
TOOL USED TO ASSESS SCORE: hand-slit lamp (1 and 4h, days 1,2,3,7,14)/ biomicroscope and fluorescein on the day after treatment
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- without flushing
- Time point:
- other: 24, 48 and 72 h
- Remarks on result:
- other: no findings on iris observed
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- without flushing
- Time point:
- other: 1h, 4h, days 1 and 2
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other: scattered cloudiness
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- no flushing
- Time point:
- other: 1 and 4h
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: mild redness
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- without flushing
- Time point:
- other: 1 and 4h
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: slight swelling
- Irritation parameter:
- other: conjunctivae - discharge
- Basis:
- animal #1
- Remarks:
- wihtout flushing
- Time point:
- other: 1 - 4h, 2- 7 days
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: mild, haemastix positive on day 2 and 3
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- eye flushed
- Time point:
- other: 4h
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: slightly injected iris
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: all
- Remarks on result:
- other: no chemosis observed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- eye flushed
- Time point:
- other: 1 - 4h
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: slight redness
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- eye flushed
- Time point:
- other: day 1
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: general cloudiness
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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