4-methylpentan-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1951

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

RANGE-FINDING TOXICITY DATA: LIST IV

Author:

Smyth HF, Carpenter CP & Weil CS

Year:

1951

Bibliographic source:

AMA Arch Ind Hyg Occup Med (1951) 4:119-122

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1948

Report date:

1948

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

Insufficient reporting of methodology and individual results

GLP compliance:

no

Remarks:

study pre-dates GLP requirements

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-methylpentan-2-ol

EC Number:

203-551-7

EC Name:

4-methylpentan-2-ol

Cas Number:

108-11-2

Molecular formula:

C6H14O

IUPAC Name:

4-methylpentan-2-ol

Details on test material:

- Name of test material (as cited in study report): 4-methyl-2-pentanol (methyl isobutyl carbinol)

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Fasting period before study: None
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

VEHICLE
- Concentration in vehicle: Not reported
- Amount of vehicle (if gavage): Not reported
- Justification for choice of vehicle: Not reported
- Lot/batch no. (if required): Not reported
- Purity: Not reported


MAXIMUM DOSE VOLUME APPLIED: Not reported

Doses:

Not reported

No. of animals per sex per dose:

Not reported

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Not reported
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Not reported

Statistics:

Standard deviations for LD50 value calculated by the method of Thompson

Results and discussion

Preliminary study:

Not applicable

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 590 mg/kg bw

95% CL:

2 260 - 2 970

Mortality:

Not reported

Clinical signs:

other: Not reported

Gross pathology:

Not reported

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)

Executive summary:

The potential acute oral toxicity of methyl i-butylcarbinol was assessed in rats. Although this study is lacking in methodological details, the work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, the results reported by this group are deemed reliable. In this investigation, the LD50 of methyl i-butylcarbinol in rats was 2590 mg/kg body weight.