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Diss Factsheets
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EC number: 202-525-2 | CAS number: 96-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The data concern a literature study; GLP conditions or Guidelines for testing are not mentioned, but the study is well performed and documented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Radiolabelled 4,4'-Thiobis(6-tert-butyl-3-cresol) was administered to rats or mice by means of oral gavage, i.v. injection, or dermal application. After 72 hours, all animals were killed and the amount of radiolabel in the carcass, faeces and urine was determined.
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Name of test material (as cited in study report): TBBC
- Analytical purity: > 96%
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- other: rat and mice
- Strain:
- other: femal sencar mice and male fischer rats
Administration / exposure
- Type of coverage:
- other: metal perforated tissue capsule
- Vehicle:
- other: ethanol/aceton mixture
- Duration of exposure:
- 72 hours
- Doses:
- See results section table 1.
- Details on study design:
- TEST SITE
- Preparation of test site: clipped
- Area of exposure: 4.2 cm2
- % coverage:
- Type of cover / wrap if used:
- Time intervals for shavings or clipplings:
SITE PROTECTION / USE OF RESTRAINERS FOR PREVENTING INGESTION: yes
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
- Absorption in different matrices:
- -See Table 1 below
- Total recovery:
- - Total recovery: averaged 93% of applied dose
Any other information on results incl. tables
Table 1 Effect of route of exposure on faecal elimination and skin retention of 6,6’-di-tert-butyl-4,4’-thiodi-m-cresol-derived radioactivity in Sencar mice and Fischer rats.
species |
exposure route (dose in mg/kg bw) |
% IBBain daily faecal excretions day 1 day 2 day 3 |
% IBB in total faecal excretions |
% IBB on treated skin site |
mouse
rat |
intravenous (5) oral (5) dermal (5) intravenous (5) oral (5) dermal (5) dermal (50) dermal (200) |
59 18 17 89* 6.5 2* 5** 9 8 - - - - - - - - - - - - - - - |
94 96 22** 77b 103b 1.7*** 0.3 0.4 |
76
98 100 100 |
* p<0.05 vs. intravenous treatment; ** p<0.01 vs. oral or intravenous treatment; *** p<0.05 vs. doses of 50 or 200 mg/kg bw.
a IBB = internal body burden, i.e., the total accountable radioactivity representing the sum of the radioactivity in the excreta, skin site, and carcass. It averaged 93% of the applied dose.
b Data from Birnbaum 1983
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of 14C-labelled 4,4'-thiobis(6-tert-butyl-m-cresol) (TBBC) was studied in female Sencar mice and male Fischer rats. Dermal application resulted in about 20% absorption in mice with more than 70% of the initial body burden (IBB) remaining on the treated skin site 3 days after treatment.
In rats, less than 20% of a dermal dose was absorbed. Absorption did not increase linearly as the dose increased. Oral and i.v. exposures were conducted in the Sencar mice and compared to previously published rat oral and i.v. data. The disposition was similar between rats and mice after these routes of exposures, and the major route of elimination of absorbed TBBC was the feces in both species.
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