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EC number: 406-880-6 | CAS number: 88917-22-0 ACETATE DPMA ACROSOLV; ACROSOLV DPMA ACETAT; ACROSOLV DPMA ACETATE; DOWANOL DPMA; DOWANOL DPMA GLYCOL ETHER; DOWANOL DPMA GLYKOL ETHER; ETHER DE GLYCOL DPMA DOWANOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 556 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 3
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 65 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Additional information - workers
No DNELs for acute exposure have been derived for dipropylene glycol methyl ether acetate as this substance is not classified for acute toxicity by any route and no acute effects have been observed in the repeated exposure studies.
Dipropylene glycol methyl ether acetate did not show any adverse effects regarding sensitization, mutagenicity or reproductive toxicity. Therefore, no DNELs have been derived for these endpoints.
No DNELs have been derived for local effects as no such effects were observed in any of the repeated dose studies. Therefore, the DNELs for systemic effects are considered to be sufficiently protective for potential local effects.
Worker-DNEL long-term for inhalation route
Based on toxicokinetics data summarized in section 5.1.3 (IUCLID chapter 7.1.1), dipropylene glycol methyl ether acetate is expected to be rapidly hydrolyzed to yield dipropylene glycol methyl ether. Thus, it is appropriate to conclude that the acetate behaves in a similar way to the parent ether due to the rapid conversion. Therefore, data on dipropylene glycol methyl ether are used to support the dataset for dipropylene glycol methyl ether acetate.
The relevant dose-descriptor for long-term exposure via the inhalation route is the NOAEL of > 200 ppm (or mg/kg bw/d) from the 13-week inhalation toxicity study with dipropylene glycol methyl ether in rats. For the DNEL calculation we have deviated from the default approach as prescribed in the ECHA guidance documents, for the following reasons. The EU Scientific Committee for Occupational Exposure Limits (SCOEL) and the German MAK Commission have established a workplace exposure level of 50 ppm for dipropylene glycol methyl ether. Based on analogy with the toxicological profile of dipropylene glycol methyl ether and the toxicokinetic behaviour of dipropylene glycol methyl ether acetate (rapid hydrolysis in the blood to dipropylene glycol methyl ether), 50 ppm is used as the Worker-DNEL-long term for the inhalation route for dipropylene glycol methyl ether acetate.
Worker-DNEL long-term for dermal route
No repeated dose study with dermal exposure is available for dipropylene glycol methyl ether acetate. The 13-week inhalation study conducted with dipropylene glycol methyl etherwas selected as the most relevant study for determining the DNEL because of the relevance of the route for repeated exposure.The relevant dose-descriptor for long-term exposure via the dermal route is the worker-DNEL of 50 ppm established for dipropylene glycol methyl ether by the SCOEL and the German MAK Commission based on the 13-week inhalation toxicity studies in rats and rabbits. The dose descriptor has been converted into a dermal dose of 65 mg/kg bw/day according to the guidance document (ECHA, Chapter R.8). No additional assessment factors have been applied for inter- and intra-species differences as the starting point was the worker-DNEL for inhalation exposure.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 46 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 2
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 15 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 2
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General population-DNEL long-term for inhalation route
For the DNEL calculation we have deviated from default approach as described in the ECHA guidance documents, for the reasons mentioned above. The dose descriptor used was the worker-DNEL-long term for the inhalation route which was corrected for the differences in duration of exposure between worker and consumer (24h per day, 7 days per week) and the intra-species difference.
General population-DNEL long-term for dermal route
No repeated dose study with dermal exposure is available for dipropylene glycol methyl ether acetate. The 13-week inhalation study was selected as the most relevant study for determining the DNEL because of the relevance of the route for repeated exposure.The relevant dose-descriptor for long-term exposure via the dermal route is the worker-DNEL of 50 ppm based on the 13-week inhalation toxicity studies in rats and rabbits. The dose descriptor was corrected for exposure conditions - according to the guidance document - as the test material was administered 5 days per week. No correction for inter-species differences was done as the starting point was the worker-DNEL for inhalation exposure. To correct for intra-species differences and for differences in the duration of exposure (sub-chronic to chronic) the default assessment factors as specified in the guidance document (Chapter R.8) have been used to calculate the DNEL.
General population-DNEL long-term for oral route
The relevant dose-descriptor for long-term exposure via the oral route is the NOAEL of 1000 mg/kg bw/day from a 28-day oral gavage study in rats. A correction of the dose descriptor for exposure conditions is not needed as the test material was administered 7 days per week. To correct for inter- and intra-species differences and for differences in the duration of exposure (sub-chronic to chronic) the default assessment factors as specified in the guidance document (Chapter R.8) have been used to calculate the DNEL.
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