Registration Dossier
Registration Dossier
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EC number: 249-854-8 | CAS number: 29797-40-8
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In a FELS study, 3,4-dichlorotoluene showed a NOEC of 0.078 mg/L in any of the endpoints determined: percent hatch, percent abnormal, dead fry immediately after hatch, percent survival of transferred fry throughout the exposure period, length and weight of juvenile fish at the exposure end.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.078 mg/L
Additional information
Key study
The 31 - 33 d (28 day-post hatched) toxicity of 3,4-dichlorotoluene was determined in a flow-through test with Pimephales promelas following a method equivalent to the OECD Guideline 210. Analytical monitoring was performed. The following parameters were determined: percent hatch, percent abnormal, dead fry immediately after hatch, percent survival of transferred fry throughout the exposure period, length and weight of juvenile fish at the exposure end.
The NOEC was determined to be 0.078 mg/L (33 d) for all parameters. The LOEC was determined to be 0.148 mg/L (28 d) based on the parameters fry survival and standard length (measured values).
Reference: Call et al, 1985
The similarities between the isomers concerning chemical structure and key intrinsic properties such as log kow and water solubility as well as nearly identical results for acute fish toxicity obtained for the mixture and individual isomers justify read across from tests results obtained with the individual isomers 2,4-DCT and 3,4-DCT to the mixture. A more detailed argumentation for read-across is given in the Summary "Aquatic toxicity".
Further study
The prolonged toxicity of 2,4-dichlorotoluene and 3,4-dichlorotoluene to Poecilia reticulata was determined in semi-static tests over a period of 14 and 7 days, respectively. The test substance concentrations were arranged with geometric regression factor of 1.8 for 2,4-dichlorotoluene and of 3.2 for 3,4 -dichlorotoluene.
A 14-d-log LC50 of 1.46 µmol/L was determined for 2,4-dichlorotoluene, which corresponds to a LC50 of 4.6 mg/L.
A 7-d-log LC50 of 1.5 µmol/L was determined for 3,4-dichlorotoluene, which corresponds to a LC50 of 5.1 mg/L.
The study is considered not to be reliable.
Reference: Könemann, 1979
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